SF3B2 and FRA10AC1

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SF3B2	FRA10AC1
Gene Name		splicing factor 3b, subunit 2, 145kDa	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Catalytic Step 2 Spliceosome	Nucleus
	Molecular Function	Protein Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression Viral Process
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		25 interactors: APBB1 APP C7orf25 C8orf33 CSNK2A1 ERG FRA10AC1 HNRNPC KDM1A KIAA0368 LSM2 LSM3 PCBP2 PRPF40A RBM7 RBM8A SF3B4 SMAD3 SNRNP200 TCERG1 THOC1 TOE1 TTC14 U2AF1 ZCCHC10	27 interactors: ADPRHL2 C21orf33 C7orf25 CCDC155 CHERP CWC27 DGCR14 EEF1D GDPD2 GLRX3 HABP4 IK LPPR4 MAP3K12 MFAP1 NKAP PRPF3 PRPF40A SAP30BP SF3B2 THOC1 TRIM41 TTC14 U2AF1 VPS29 ZCCHC10 ZNF830
Entrez ID		10992	118924
HPRD ID		10410	12319
Ensembl ID		ENSG00000087365	ENSG00000148690
Uniprot IDs		Q13435	Q70Z53
PDB IDs		2DO5
Enriched GO Terms of Interacting Partners?		RNA Processing MRNA Processing RNA Splicing MRNA Metabolic Process RNA Metabolic Process Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process MRNA Export From Nucleus Transcription, DNA-templated RNA Export From Nucleus RNA Biosynthetic Process MRNA 3'-end Processing Regulation Of Cell Cycle RNA 3'-end Processing Nuclear Export MRNA Transport Regulation Of Response To DNA Damage Stimulus Osteoblast Differentiation RNA Transport Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process RNA Localization MRNA Catabolic Process Regulation Of Gene Expression Negative Regulation Of Cell Cycle RNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Macromolecule Catabolic Process Metabolic Process Termination Of RNA Polymerase II Transcription Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle Process Negative Regulation Of Protein Metabolic Process Apoptotic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Thymidylate Synthase Biosynthetic Process Negative Regulation Of Potassium Ion Export Negative Regulation Of Isotype Switching To IgA Isotypes	RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Chromosome Localization To Nuclear Envelope Involved In Synapsis Negative Regulation Of Isotype Switching To IgA Isotypes MRNA Export From Nucleus RNA Export From Nucleus Metabolic Process Intestinal Epithelial Structure Maintenance
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