MSL3 and KAT8

Number of citations of the paper that reports this interaction (PMID 20479123)
49

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MSL3	KAT8
Gene Name		male-specific lethal 3 homolog (Drosophila)	K(lysine) acetyltransferase 8
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm MSL Complex	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Nuclear Membrane MLL1 Complex MSL Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Methylated Histone Binding	Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Enzyme Binding Methylated Histone Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Metal Ion Binding Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Chromatin Organization Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Histone H4-K16 Acetylation	Chromatin Organization Transcription, DNA-templated Regulation Of Autophagy Histone Acetylation Myeloid Cell Differentiation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: APP CDK6 HIST1H3A HIST1H4A HIST3H3 HIST4H4 KAT8 PAF1	11 interactors: ATM BAZ2A FOXP3 HIST1H4A KANSL1 KMT2A MSL1 MSL3 PAF1 RNF2 TP53
Entrez ID		10943	84148
HPRD ID		05344	11381
Ensembl ID		ENSG00000005302	ENSG00000103510
Uniprot IDs		B7Z227 Q8N5Y2	Q9H7Z6
PDB IDs		2Y0N 3OA6 3OB9	2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Nucleosome Assembly DNA Methylation On Cytosine Negative Regulation Of Myeloid Cell Differentiation Chromatin Silencing At RDNA Chromatin Silencing Chromosome Organization Regulation Of Myeloid Cell Differentiation Histone H4-K20 Demethylation DNA Methylation Negative Regulation Of Megakaryocyte Differentiation Chromatin Organization Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance DNA Modification Negative Regulation Of Immune System Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Gene Silencing Histone Modification Nucleosome Assembly Chromatin Assembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Nucleosome Organization Negative Regulation Of RNA Biosynthetic Process Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Regulation Of Megakaryocyte Differentiation DNA Packaging Negative Regulation Of Gene Expression Chromatin Modification Negative Regulation Of Biosynthetic Process Homeostatic Process CENP-A Containing Nucleosome Assembly Regulation Of Gene Expression, Epigenetic MRNA Polyadenylation Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange DNA Replication-independent Nucleosome Assembly Histone Lysine Demethylation Regulation Of Cell Differentiation Histone Demethylation RNA Polyadenylation Nucleobase-containing Compound Metabolic Process Protein Demethylation DNA Conformation Change Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression	Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Histone H4-K16 Acetylation Organelle Organization Histone H4 Acetylation Peptidyl-lysine Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Chromosome Organization DNA Methylation Negative Regulation Of Transcription, DNA-templated Anterior/posterior Pattern Specification Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Histone Modification Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Proliferation DNA Modification Replicative Senescence Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Silencing At RDNA Transcription, DNA-templated Negative Regulation Of Immune System Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Histone Modification RNA Biosynthetic Process Regulation Of Gene Expression Chromatin Assembly Cellular Nitrogen Compound Metabolic Process Histone Monoubiquitination Chromatin Assembly Or Disassembly Pattern Specification Process DNA Metabolic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Chromatin Remodeling DNA Packaging
Tagcloud ?		achieve analyze chip chromodomain chromodomains compensation counterparts disruption dosage drosophila entry flanking h3k36me3 lethal marked melanogaster mutants nucleosomal nucleosomes preferential respective retain similarly spread spreading targeting trimethylation upregulates	acetylated acetylation acetyltransferase acetyltransferases alter broad compaction compensation decompact dosage embryonic enhancers ep300 escs flies h3k27 h3k4me1 h4 h4k16 h4k16ac histone interest marked marks nucleosomes peaks start surprisingly tails
Tagcloud (Difference) ?		achieve analyze chip chromodomain chromodomains counterparts disruption drosophila entry flanking h3k36me3 lethal melanogaster mutants nucleosomal preferential respective retain similarly spread spreading targeting trimethylation upregulates	acetylated acetylation acetyltransferase acetyltransferases alter broad compaction decompact embryonic enhancers ep300 escs flies h3k27 h3k4me1 h4 h4k16 h4k16ac histone interest marks peaks start surprisingly tails
Tagcloud (Intersection) ?		compensation dosage marked nucleosomes