MSL3 and HIST4H4

Number of citations of the paper that reports this interaction (PMID 20943666)
9

Data Source:
BioGRID (unspecified method)

		MSL3	HIST4H4
Gene Name		male-specific lethal 3 homolog (Drosophila)	histone cluster 4, H4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm MSL Complex	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Methylated Histone Binding	DNA Binding Protein Binding Histone Demethylase Activity (H4-K20 Specific) Poly(A) RNA Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Organization Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Histone H4-K16 Acetylation	Chromatin Silencing At RDNA Mitotic Cell Cycle Telomere Maintenance Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Gene Expression DNA Methylation On Cytosine CENP-A Containing Nucleosome Assembly Histone H4-K20 Demethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS			Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		8 interactors: APP CDK6 HIST1H3A HIST1H4A HIST3H3 HIST4H4 KAT8 PAF1	52 interactors: ANP32A ARID4A ASF1A ASF1B BRD2 BRD4 BRD7 CBX5 CDY1 COPRS CREBBP DAXX DNTTIP2 EP300 GADD45A HAT1 HDAC6 HDAC8 HDAC9 ING1 ING2 KAT2A KAT2B KAT6A L3MBTL1 LRWD1 MSL3 NCOA2 NCOA3 NOC2L NSD1 ORC2 ORC3 ORC4 ORC5 PRMT1 PRMT6 RAG1 RPS6KA5 SAP30 SET SETD8 SETDB1 SIAH1 SMARCA5 TAF1A TP53BP1 UBE2I UCHL5 USP16 VHL WDR5
Entrez ID		10943	121504
HPRD ID		05344	13662
Ensembl ID		ENSG00000005302	ENSG00000197837
Uniprot IDs		B7Z227 Q8N5Y2	B2R4R0 P62805
PDB IDs		2Y0N 3OA6 3OB9	2BQZ 2CV5 2KWN 2KWO 2LVM 2QQS 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3NQJ 3NQU 3O36 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Nucleosome Assembly DNA Methylation On Cytosine Negative Regulation Of Myeloid Cell Differentiation Chromatin Silencing At RDNA Chromatin Silencing Chromosome Organization Regulation Of Myeloid Cell Differentiation Histone H4-K20 Demethylation DNA Methylation Negative Regulation Of Megakaryocyte Differentiation Chromatin Organization Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance DNA Modification Negative Regulation Of Immune System Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Gene Silencing Histone Modification Nucleosome Assembly Chromatin Assembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Nucleosome Organization Negative Regulation Of RNA Biosynthetic Process Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Regulation Of Megakaryocyte Differentiation DNA Packaging Negative Regulation Of Gene Expression Chromatin Modification Negative Regulation Of Biosynthetic Process Homeostatic Process CENP-A Containing Nucleosome Assembly Regulation Of Gene Expression, Epigenetic MRNA Polyadenylation Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange DNA Replication-independent Nucleosome Assembly Histone Lysine Demethylation Regulation Of Cell Differentiation Histone Demethylation RNA Polyadenylation Nucleobase-containing Compound Metabolic Process Protein Demethylation DNA Conformation Change Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression	Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Peptidyl-lysine Modification Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Organelle Organization Macromolecule Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Peptidyl-amino Acid Modification Gene Expression RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Chromatin Assembly Or Disassembly Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Assembly Positive Regulation Of Transcription, DNA-templated Histone H3-K9 Modification Histone Methylation Positive Regulation Of Gene Expression Cell Cycle Nucleosome Assembly DNA Packaging
Tagcloud ?		achieve analyze chip chromodomain chromodomains compensation counterparts disruption dosage drosophila entry flanking h3k36me3 lethal marked melanogaster mutants nucleosomal nucleosomes preferential respective retain similarly spread spreading targeting trimethylation upregulates
Tagcloud (Difference) ?		achieve analyze chip chromodomain chromodomains compensation counterparts disruption dosage drosophila entry flanking h3k36me3 lethal marked melanogaster mutants nucleosomal nucleosomes preferential respective retain similarly spread spreading targeting trimethylation upregulates
Tagcloud (Intersection) ?