CGA and LHB

Number of citations of the paper that reports this interaction (PMID 7679977)
2

Data Source:
HPRD (in vivo, in vitro)

		CGA	LHB
Gene Name		glycoprotein hormones, alpha polypeptide	luteinizing hormone beta polypeptide
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region	Extracellular Region Extracellular Vesicular Exosome
	Molecular Function	Hormone Activity Protein Binding	Receptor Binding Hormone Activity
	Biological Process	Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Peptide Hormone Processing Positive Regulation Of Cell Migration Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter	Progesterone Biosynthetic Process Signal Transduction Cell-cell Signaling Male Gonad Development Peptide Hormone Processing Cellular Protein Metabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Amine-derived hormones Metabolism of lipids and lipoproteins Mineralocorticoid biosynthesis G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Androgen biosynthesis Metabolism of amino acids and derivatives Metabolism of steroid hormones and vitamin D Peptide hormone metabolism GPCR downstream signaling Glycoprotein hormones Thyroxine biosynthesis Peptide hormone biosynthesis	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Metabolism of lipids and lipoproteins Mineralocorticoid biosynthesis G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Androgen biosynthesis Metabolism of steroid hormones and vitamin D Peptide hormone metabolism GPCR downstream signaling Glycoprotein hormones Peptide hormone biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CGB CGB5 FSHB LHB LHCGR PTN PTPN12 TSHB	4 interactors: CGA GNAI2 GNAS LHCGR
Entrez ID		1081	3972
HPRD ID		00342	01072
Ensembl ID		ENSG00000135346	ENSG00000104826
Uniprot IDs		P01215 Q6I9S8	P01229
PDB IDs		1DZ7 1E9J 1FL7 1HCN 1HD4 1HRP 1QFW 1XUL 1XWD 4AY9	1M92
Enriched GO Terms of Interacting Partners?		Peptide Hormone Processing Peptide Metabolic Process Hormone Metabolic Process Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels Female Gamete Generation Progesterone Biosynthetic Process Male Gonad Development Single Organism Reproductive Process Progesterone Metabolic Process C21-steroid Hormone Biosynthetic Process Reproductive Process Male Sex Differentiation C21-steroid Hormone Metabolic Process Gonad Development Development Of Primary Sexual Characteristics Sex Differentiation Cell-cell Signaling Hormone Biosynthetic Process Signal Transduction Signaling Cell Communication Cellular Ketone Metabolic Process Reproductive Structure Development Reproductive System Development Steroid Biosynthetic Process Cellular Protein Metabolic Process Cellular Response To Stimulus Luteinizing Hormone Signaling Pathway Gamete Generation Developmental Process Involved In Reproduction Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Follicle-stimulating Hormone Signaling Pathway Sertoli Cell Proliferation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein Metabolic Process Steroid Metabolic Process Regulation Of Inositol Trisphosphate Biosynthetic Process Response To Stimulus Positive Regulation Of Inositol Phosphate Biosynthetic Process Reproduction Cognition Positive Regulation Of CAMP-mediated Signaling G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Bone Resorption Regulation Of CAMP-mediated Signaling	Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of CAMP-mediated Signaling Regulation Of CAMP-mediated Signaling Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Cellular Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Post-embryonic Body Morphogenesis Platelet Activation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Metabolic Process Luteinizing Hormone Signaling Pathway Positive Regulation Of Signal Transduction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Cognition Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Biosynthetic Process Regulation Of Inositol Trisphosphate Biosynthetic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Inositol Phosphate Biosynthetic Process Blood Coagulation Hemostasis Regulation Of Nitrogen Compound Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin E Stimulus Response To Parathyroid Hormone Adenosine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Signal Transduction Adrenergic Receptor Signaling Pathway Hair Follicle Placode Formation Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Signaling Regulation Of Body Fluid Levels Negative Regulation Of Multicellular Organism Growth Cellular Response To Hormone Stimulus Cell Communication Negative Regulation Of Adenylate Cyclase Activity
Tagcloud ?		aberrations arginine codon documented encode faulty finger fingers gonads hotspot mesothelium mobility mutational nonsense spleen sscp stop strand substituted tga tumours urogenital uterus wilms wt wt1 wts zf3 zinc	action antiserum collectively dynamically exhibiting follicles follicular folliculogenesis gonad grown hcg igf1 igf1rs igf2a igf2b igf3 igfs luteinizing maturation mediating mediators oocyte reaching rescue stimulatory unexplored vertebrates zebrafish
Tagcloud (Difference) ?		aberrations arginine codon documented encode faulty finger fingers gonads hotspot mesothelium mobility mutational nonsense spleen sscp stop strand substituted tga tumours urogenital uterus wilms wt wt1 wts zf3 zinc	action antiserum collectively dynamically exhibiting follicles follicular folliculogenesis gonad grown hcg igf1 igf1rs igf2a igf2b igf3 igfs luteinizing maturation mediating mediators oocyte reaching rescue stimulatory unexplored vertebrates zebrafish
Tagcloud (Intersection) ?