TGOLN2 and PRKD2

Number of citations of the paper that reports this interaction (PMID 14743217)
72

Data Source:
HPRD (in vitro)

		TGOLN2	PRKD2
Gene Name		trans-golgi network protein 2	protein kinase D2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Trans-Golgi Network Plasma Membrane Integral Component Of Membrane Transport Vesicle	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane
	Molecular Function	Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process		Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Protein Phosphorylation Cell Adhesion Cell Death Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Endothelial Tube Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase D Signaling Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS			Chronic lymphocytic leukemia ( 18758461)
Protein-Protein Interactions		10 interactors: AP1M1 AP1M2 AP2M1 AP3M1 AP4M1 ITGB1 KRTAP10-9 PPP1R9A PPP1R9B PRKD2	17 interactors: CASK DST GLRX3 GORASP1 GRIP1 HDAC7 HEY1 IFNAR1 MTF2 PDLIM7 PFDN1 PSG3 RARB RRBP1 RXRA SNRNP70 TGOLN2
Entrez ID		10618	25865
HPRD ID		04343	09523
Ensembl ID		ENSG00000152291	ENSG00000105287
Uniprot IDs		O43493	M0QZW1 M0R2R2 Q8NCK8 Q9BZL6
PDB IDs			2COA 3BGM
Enriched GO Terms of Interacting Partners?		Regulation Of Defense Response To Virus By Virus Intracellular Protein Transport Cellular Protein Localization Protein Transport Regulation Of Defense Response To Virus Establishment Of Protein Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Intracellular Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Protein Localization Establishment Of Localization In Cell Viral Process Regulation Of Immune System Process Cellular Localization Antigen Processing And Presentation Of Peptide Antigen Vesicle-mediated Transport Golgi Vesicle Transport Antigen Processing And Presentation Neuron Projection Development Regulation Of Protein Localization To Plasma Membrane Membrane Organization Neuron Development Neuron Differentiation Calcium-mediated Signaling Cell Projection Organization Immune System Process Protein Kinase D Signaling Regulation Of Opioid Receptor Signaling Pathway Cellular Response To Morphine Positive Regulation Of Histone Deacetylase Activity Regulation Of Collagen Catabolic Process Dendrite Development Actin Cytoskeleton Organization Response To Growth Factor Second-messenger-mediated Signaling Actin Filament-based Process Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Isoquinoline Alkaloid Calcium-independent Cell-matrix Adhesion Regulation Of Cell Growth By Extracellular Stimulus Movement Of Cell Or Subcellular Component Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Generation Of Neurons Formation Of Radial Glial Scaffolds Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Histone Deacetylase Activity Cytoplasmic Transport Positive Regulation Of Deacetylase Activity	Positive Regulation Of Gene Expression Regulation Of Osteoblast Differentiation Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Chamber Development Developmental Process Positive Regulation Of Transcription, DNA-templated Retinoic Acid Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Cellular Response To Steroid Hormone Stimulus Multicellular Organismal Development Cardiac Muscle Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ossification Intracellular Receptor Signaling Pathway Heart Development Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heart Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Glandular Epithelial Cell Differentiation Cellular Response To Hormone Stimulus Negative Regulation Of Transcription, DNA-templated Ventricular Cardiac Muscle Tissue Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cardiac Muscle Tissue Morphogenesis Cardiac Septum Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Ossification Regulation Of RNA Metabolic Process Muscle Tissue Morphogenesis Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Positive Regulation Of Osteoblast Differentiation Striated Muscle Tissue Development Negative Regulation Of Cell Differentiation Muscle Cell Differentiation Negative Regulation Of Gene Expression Muscle Tissue Development Negative Regulation Of Biosynthetic Process Positive Regulation Of Translational Initiation By Iron Cardiac Septum Development Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Vasculogenesis Positive Regulation Of Ossification
Tagcloud ?			a172 cdk2 crt0066101 dismal e2f1 gbm gbm2 gli25 glioblastoma glioma gliomagenesis gm133 hallmarks hypophosphorylation mer multiforme mut p15 pkb pkc prb profoundly retinoblastoma senescence silencing t98g u251 u87mg
Tagcloud (Difference) ?			a172 cdk2 crt0066101 dismal e2f1 gbm gbm2 gli25 glioblastoma glioma gliomagenesis gm133 hallmarks hypophosphorylation mer multiforme mut p15 pkb pkc prb profoundly retinoblastoma senescence silencing t98g u251 u87mg
Tagcloud (Intersection) ?