PRKD2 and RARB

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)

		PRKD2	RARB
Gene Name		protein kinase D2	retinoic acid receptor, beta
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Metal Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA Binding Steroid Hormone Receptor Activity Retinoic Acid Receptor Activity Protein Binding Drug Binding Zinc Ion Binding Protein Complex Binding Retinoid X Receptor Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Protein Phosphorylation Cell Adhesion Cell Death Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Endothelial Tube Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase D Signaling Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Retinal Pigment Epithelium Development Growth Plate Cartilage Development Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Gene Expression Striatum Development Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Embryonic Digestive Tract Development Ventricular Cardiac Muscle Cell Differentiation Transmembrane Transport
Pathways			Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters
Drugs			Adapalene Acitretin Alitretinoin Tazarotene Etretinate TTNPB Tamibarotene
Diseases
GWAS		Chronic lymphocytic leukemia ( 18758461)	Airflow obstruction ( 22837378) Obesity (extreme) ( 19553259) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		17 interactors: CASK DST GLRX3 GORASP1 GRIP1 HDAC7 HEY1 IFNAR1 MTF2 PDLIM7 PFDN1 PSG3 RARB RRBP1 RXRA SNRNP70 TGOLN2	19 interactors: CCNH CEBPA CEBPB EIF3I GATA3 HR MAP6 MEOX2 NCOA1 NCOA3 NCOR2 NR4A2 PNRC1 PRKD2 RXRA RXRB RXRG SMAD2 SRC
Entrez ID		25865	5915
HPRD ID		09523	07183
Ensembl ID		ENSG00000105287	ENSG00000077092
Uniprot IDs		M0QZW1 M0R2R2 Q8NCK8 Q9BZL6	F1D8S6 P10826 Q5QHG3
PDB IDs		2COA 3BGM	1HRA 1XAP 4DM6 4DM8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Regulation Of Osteoblast Differentiation Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Chamber Development Developmental Process Positive Regulation Of Transcription, DNA-templated Retinoic Acid Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Cellular Response To Steroid Hormone Stimulus Multicellular Organismal Development Cardiac Muscle Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ossification Intracellular Receptor Signaling Pathway Heart Development Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heart Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Glandular Epithelial Cell Differentiation Cellular Response To Hormone Stimulus Negative Regulation Of Transcription, DNA-templated Ventricular Cardiac Muscle Tissue Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cardiac Muscle Tissue Morphogenesis Cardiac Septum Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Ossification Regulation Of RNA Metabolic Process Muscle Tissue Morphogenesis Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Positive Regulation Of Osteoblast Differentiation Striated Muscle Tissue Development Negative Regulation Of Cell Differentiation Muscle Cell Differentiation Negative Regulation Of Gene Expression Muscle Tissue Development Negative Regulation Of Biosynthetic Process Positive Regulation Of Translational Initiation By Iron Cardiac Septum Development Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Vasculogenesis Positive Regulation Of Ossification	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Response To Lipid Regulation Of Gene Expression Gene Expression Regulation Of Transcription, DNA-templated Response To Steroid Hormone Regulation Of Nucleic Acid-templated Transcription Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process In Utero Embryonic Development Macromolecule Biosynthetic Process Cellular Response To Organic Substance Chordate Embryonic Development Intracellular Receptor Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Regulation Of Nitrogen Compound Metabolic Process Response To Organic Cyclic Compound Response To Hormone Gland Development Reproductive Structure Development Reproductive System Development Response To Organic Substance Embryo Development Biosynthetic Process Placenta Development System Development Positive Regulation Of Metabolic Process Tissue Development Regulation Of Metabolic Process Cellular Response To Organic Cyclic Compound Organ Development Nucleobase-containing Compound Metabolic Process Developmental Process Involved In Reproduction Epithelium Development Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process
Tagcloud ?		a172 cdk2 crt0066101 dismal e2f1 gbm gbm2 gli25 glioblastoma glioma gliomagenesis gm133 hallmarks hypophosphorylation mer multiforme mut p15 pkb pkc prb profoundly retinoblastoma senescence silencing t98g u251 u87mg	activating backcross chromosomes contain cosegregated enhancers fragment homology interspecific loci mapped mchr mediate none rara rarg reports responsive restriction retinoic retinoid rflvs rxr subclass syntenic terms trans variants
Tagcloud (Difference) ?		a172 cdk2 crt0066101 dismal e2f1 gbm gbm2 gli25 glioblastoma glioma gliomagenesis gm133 hallmarks hypophosphorylation mer multiforme mut p15 pkb pkc prb profoundly retinoblastoma senescence silencing t98g u251 u87mg	activating backcross chromosomes contain cosegregated enhancers fragment homology interspecific loci mapped mchr mediate none rara rarg reports responsive restriction retinoic retinoid rflvs rxr subclass syntenic terms trans variants
Tagcloud (Intersection) ?