PDLIM5 and PRKCG

Number of citations of the paper that reports this interaction (PMID 8940095)
46

Data Source:
HPRD (two hybrid)

		PDLIM5	PRKCG
Gene Name		PDZ and LIM domain 5	protein kinase C, gamma
Image
Gene Ontology Annotations	Cellular Component	Cytosol Postsynaptic Density Actin Cytoskeleton Membrane Z Disc Cell Junction Neuron Projection Postsynaptic Membrane	Nucleus Cytosol Plasma Membrane Cell-cell Junction Dendrite Perinuclear Region Of Cytoplasm Synaptic Membrane
	Molecular Function	Actin Binding Protein Kinase C Binding Zinc Ion Binding Actinin Binding Protein N-terminus Binding	Protein Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Serine/threonine/tyrosine Kinase Activity ATP Binding Zinc Ion Binding
	Biological Process	Regulation Of Synapse Assembly Regulation Of Dendritic Spine Morphogenesis	Protein Phosphorylation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Blood Coagulation Learning Or Memory Chemosensory Behavior Fibroblast Growth Factor Receptor Signaling Pathway Phosphorylation Platelet Activation Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Response To Pain Rhythmic Process Innervation Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways			Signaling by GPCR Ca-dependent events CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAP12 signaling Response to elevated platelet cytosolic Ca2+ G alpha (z) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signaling by PDGF Calmodulin induced events DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Downstream signal transduction Calmodulin induced events WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Platelet activation, signaling and aggregation PCP/CE pathway Transmission across Chemical Synapses Trafficking of GluR2-containing AMPA receptors DAG and IP3 signaling CaM pathway Downstream signaling of activated FGFR Disinhibition of SNARE formation Innate Immune System Signalling by NGF PLC beta mediated events Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Trafficking of AMPA receptors Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR beta-catenin independent WNT signaling PLC-gamma1 signalling Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
Drugs
Diseases
GWAS		Prostate cancer ( 19767753) Visceral fat ( 22589738)
Protein-Protein Interactions		13 interactors: ACTB ACTN1 CACNA1B CCDC136 COIL GFI1B KRT40 KRTAP10-7 PRKCB PRKCE PRKCG TRIM39 ZYX	58 interactors: ADRBK1 AFAP1 ANXA7 APP ARHGEF25 CASR CCHCR1 CD5 CDC42 CHAT CYTH2 DAB2 DDX58 DVL2 EIF4E EPHB1 EXOC5 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 MARK4 NFE2L2 NOXA1 NRGN NUMB PA2G4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 SCN3A SDC2 STXBP1 TIAM1 TOP2A TRIM5 VTN YWHAB YWHAE YWHAG
Entrez ID		10611	5582
HPRD ID		05799	01502
Ensembl ID		ENSG00000163110	ENSG00000126583
Uniprot IDs		B7Z481 B7Z8X5 Q96HC4	F5H5C4 P05129
PDB IDs		2DAR 2UZC	2E73 2UZP
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Pain Response To Morphine Immune Response-activating Cell Surface Receptor Signaling Pathway Activation Of Phospholipase C Activity Calcium Ion Transport Positive Regulation Of Phospholipase C Activity Cell-cell Signaling Actin Filament Bundle Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Cellular Glucuronidation Positive Regulation Of Mismatch Repair Regulation Of Phospholipase Activity Multicellular Organismal Response To Stress Adherens Junction Organization Positive Regulation Of Lipase Activity Response To Ammonium Ion Response To Stress Immune Response-regulating Signaling Pathway Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Adhesion Negative Regulation Of Protein Ubiquitination Regulation Of Mismatch Repair TRAM-dependent Toll-like Receptor 4 Signaling Pathway Histone H3-T6 Phosphorylation Negative Regulation Of Protein Catabolic Process Cellular Response To Growth Factor Stimulus Synaptic Transmission Behavior Response To Growth Factor Chromatin Modification Response To Alkaloid Positive Regulation Of Immune Response Protein Localization To Tight Junction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway	Regulation Of Signaling Regulation Of Cellular Process Signaling Nervous System Development Cell Communication Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Developmental Process Anatomical Structure Development Generation Of Neurons System Development Neuron Development Neuron Projection Development Neurogenesis Signal Transduction Positive Regulation Of Transport Regulation Of Cellular Component Organization Cell Differentiation Response To Stimulus Neuron Projection Morphogenesis Axonogenesis Neuron Differentiation Regulation Of Signal Transduction Cell Projection Organization Cellular Response To Stimulus Axon Development Glutamate Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Neuron Differentiation Enzyme Linked Receptor Protein Signaling Pathway Response To Stress Cell-cell Signaling Response To Organic Substance Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Catalytic Activity Cell Projection Morphogenesis Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Metabolic Process Cell Part Morphogenesis Ephrin Receptor Signaling Pathway Regulation Of Cellular Localization Cell Morphogenesis Regulation Of Synaptic Plasticity Axon Guidance Positive Regulation Of Catalytic Activity Neuron-neuron Synaptic Transmission Transport Regulation Of Cell Development
Tagcloud ?		14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pde6d ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2	apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd psg1 pw39 tnnt1
Tagcloud (Difference) ?		14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pde6d ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2	apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd psg1 pw39 tnnt1
Tagcloud (Intersection) ?