CDK9 and CUL1

Number of citations of the paper that reports this interaction (PMID 11689688)
29

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		CDK9	CUL1
Gene Name		cyclin-dependent kinase 9	cullin 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Transcription Elongation Factor Complex Positive Transcription Elongation Factor Complex B Membrane PML Body Intracellular Membrane-bounded Organelle	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity SnRNA Binding Transcription Regulatory Region DNA Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	DNA Repair Regulation Of DNA Repair Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Cell Proliferation Gene Expression Viral Process Regulation Of Histone Modification Replication Fork Arrest Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Negative Regulation Of Cell Cycle Arrest Cellular Response To Cytokine Stimulus	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Monoubiquitination Cell Cycle Arrest Notch Signaling Pathway Circadian Rhythm Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Viral Process Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery TGFBR1 LBD Mutants in Cancer RNA Polymerase II Pre-transcription Events SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HIV elongation arrest and recovery HIV Life Cycle Generic Transcription Pathway HIV Transcription Elongation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Host Interactions of HIV factors Loss of Function of SMAD4 in Cancer Interactions of Tat with host cellular proteins TGFBR1 KD Mutants in Cancer Pausing and recovery of Tat-mediated HIV elongation Loss of Function of TGFBR1 in Cancer Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome SMAD4 MH2 Domain Mutants in Cancer RNA Polymerase II Transcription Elongation	Signaling by the B Cell Receptor (BCR) Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Cyclin E associated events during G1/S transition Signaling by Wnt Regulation of PLK1 Activity at G2/M Transition Downstream signaling events of B Cell Receptor (BCR) Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Degradation of beta-catenin by the destruction complex G1/S Transition AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 in Cancer Prolactin receptor signaling Mitotic G1-G1/S phases truncations of AMER1 destabilize the destruction complex Signaling by NOTCH phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase S Phase Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Signaling by Interleukins SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Interleukin-1 signaling Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G2-G2/M phases Constitutive Signaling by NOTCH1 PEST Domain Mutants Adaptive Immune System Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer APC truncation mutants have impaired AXIN binding G2/M Transition APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 Class I MHC mediated antigen processing & presentation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FBXW7 Mutants and NOTCH1 in Cancer G1 Phase Cytokine Signaling in Immune system Cell Cycle, Mitotic NOTCH1 Intracellular Domain Regulates Transcription Cyclin D associated events in G1 Nuclear signaling by ERBB4 Activation of NF-kappaB in B cells SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Signaling by Hedgehog deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Degradation of GLI1 by the proteasome Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS
Protein-Protein Interactions		56 interactors: ACTL6A AFF4 AR BCL10 BRCA1 CASK CCNK CCNT1 CCNT2 CDC34 CDC7 CDK5R1 CDK7 CTD CTDP1 CTDSPL CUL1 DHX30 FBXO25 GRN GTF2F1 HEXIM1 HEXIM2 HIST2H2BE HLTF HSPA1A HTATSF1 IL6ST MBP MDFIC MED21 MYBL2 NBN NFKB1 NR2E3 PIN1 POLR2A RB1 RCHY1 RELA RMND5B RN7SK SERPINH1 SKP1 SKP2 SMAD1 SMAD2 SMAD3 STAT3 STK36 SUPT5H TAF7 TP53 TRAF2 UBE2A ZMYM6	55 interactors: ARIH1 BTRC CAND1 CDC34 CDCA3 CDK9 CDKN1B CENPE CHEK1 CHUK CKS1B COMMD1 COPS2 COPS5 COPS6 COPS7A COPS8 DCUN1D4 E2F1 FBXO18 FBXO25 FBXW11 FBXW2 FBXW4 FBXW7 GLMN GPS1 HIPK2 NEDD8 NFKBIA NFKBIB NFKBIE NLK NR1D2 PARK2 PPP1CA PRPF40A PSMB4 PSMD4 PTTG1 RAC2 RANBP2 RBX1 RICTOR RNF7 SENP8 SKP1 SKP2 SMAD3 THRA TRIM21 UBE2E3 UBE2F UBE2M ZC3HC1
Entrez ID		1025	8454
HPRD ID		16016	04389
Ensembl ID		ENSG00000136807	ENSG00000055130
Uniprot IDs		P50750	B3KTW0 Q13616
PDB IDs		1PF6 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY	1LDJ 1LDK 1U6G 3RTR 3TDU 3TDZ 4F52
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Viral Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Gene Expression RNA Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Process Transcription Initiation From RNA Polymerase II Promoter Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Viral Transcription Regulation Of Phosphorylation Regulation Of Protein Phosphorylation DNA-templated Transcription, Initiation Transcription Elongation From RNA Polymerase II Promoter Regulation Of Phosphorus Metabolic Process Biosynthetic Process Regulation Of Viral Transcription Cell Cycle Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Response To Stimulus Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle	Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Protein Ubiquitination Cellular Protein Metabolic Process Protein Deneddylation Protein Metabolic Process Cullin Deneddylation Cell Cycle Mitotic Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Proteolysis Involved In Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Cell Cycle Phase Transition Cellular Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Protein Polyubiquitination Cellular Response To Organic Substance Cellular Macromolecule Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Viral Process Cellular Response To Stimulus Response To Growth Factor Response To Organic Substance Cell Communication Protein Modification By Small Protein Removal Negative Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Regulation Of Signaling Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Regulation Of Protein Ubiquitination Signal Transduction
Tagcloud ?		affects associate bulk ccnk cdk12 cdk13 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb	autophagy box catalytic cdk checkpoint complexes cullin1 damage degradation downstream endocytosis f fbxl20 mediates mitotic phosphatidylinositol promote proteasomal provides ptdins3 ptdins3p regulate scf skp1 sorting transduction ubiquitination vacuolar vps34
Tagcloud (Difference) ?		affects associate bulk ccnk cdk12 cdk13 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb	autophagy box catalytic cdk checkpoint complexes cullin1 damage degradation downstream endocytosis f fbxl20 mediates mitotic phosphatidylinositol promote proteasomal provides ptdins3 ptdins3p regulate scf skp1 sorting transduction ubiquitination vacuolar vps34
Tagcloud (Intersection) ?