CUL1 and UBE2E3

Number of citations of the paper that reports this interaction (PMID 19256485)
6

Data Source:
BioGRID (pull down)

		CUL1	UBE2E3
Gene Name		cullin 1	ubiquitin-conjugating enzyme E2E 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Nucleus Cytoplasm
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Monoubiquitination Cell Cycle Arrest Notch Signaling Pathway Circadian Rhythm Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Viral Process Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway	Regulation Of Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Cyclin E associated events during G1/S transition Signaling by Wnt Regulation of PLK1 Activity at G2/M Transition Downstream signaling events of B Cell Receptor (BCR) Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Degradation of beta-catenin by the destruction complex G1/S Transition AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 in Cancer Prolactin receptor signaling Mitotic G1-G1/S phases truncations of AMER1 destabilize the destruction complex Signaling by NOTCH phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase S Phase Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Signaling by Interleukins SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Interleukin-1 signaling Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G2-G2/M phases Constitutive Signaling by NOTCH1 PEST Domain Mutants Adaptive Immune System Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer APC truncation mutants have impaired AXIN binding G2/M Transition APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 Class I MHC mediated antigen processing & presentation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FBXW7 Mutants and NOTCH1 in Cancer G1 Phase Cytokine Signaling in Immune system Cell Cycle, Mitotic NOTCH1 Intracellular Domain Regulates Transcription Cyclin D associated events in G1 Nuclear signaling by ERBB4 Activation of NF-kappaB in B cells SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Signaling by Hedgehog deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Degradation of GLI1 by the proteasome Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Obesity ( 21552555)
Protein-Protein Interactions		55 interactors: ARIH1 BTRC CAND1 CDC34 CDCA3 CDK9 CDKN1B CENPE CHEK1 CHUK CKS1B COMMD1 COPS2 COPS5 COPS6 COPS7A COPS8 DCUN1D4 E2F1 FBXO18 FBXO25 FBXW11 FBXW2 FBXW4 FBXW7 GLMN GPS1 HIPK2 NEDD8 NFKBIA NFKBIB NFKBIE NLK NR1D2 PARK2 PPP1CA PRPF40A PSMB4 PSMD4 PTTG1 RAC2 RANBP2 RBX1 RICTOR RNF7 SENP8 SKP1 SKP2 SMAD3 THRA TRIM21 UBE2E3 UBE2F UBE2M ZC3HC1	75 interactors: ACVR1 ARID3A ARIH2 ATXN1 BARD1 BRCA1 CADPS2 CHFR CHUK CNOT4 CUL1 CUL3 CUL4A DTX3 DTX3L DZIP3 HERC4 HTT IPO11 ITCH KLHL42 MARCH5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA RBX1 RCBTB1 RCBTB2 RFWD3 RING1 RMND5B RNF10 RNF11 RNF111 RNF114 RNF115 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBC UBOX5 UFM1 WWP2 ZNRF1 ZNRF4
Entrez ID		8454	10477
HPRD ID		04389	05000
Ensembl ID		ENSG00000055130	ENSG00000170035
Uniprot IDs		B3KTW0 Q13616	Q969T4
PDB IDs		1LDJ 1LDK 1U6G 3RTR 3TDU 3TDZ 4F52
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Protein Ubiquitination Cellular Protein Metabolic Process Protein Deneddylation Protein Metabolic Process Cullin Deneddylation Cell Cycle Mitotic Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Proteolysis Involved In Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Cell Cycle Phase Transition Cellular Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Protein Polyubiquitination Cellular Response To Organic Substance Cellular Macromolecule Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Viral Process Cellular Response To Stimulus Response To Growth Factor Response To Organic Substance Cell Communication Protein Modification By Small Protein Removal Negative Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Regulation Of Signaling Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Regulation Of Protein Ubiquitination Signal Transduction	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Metabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Autoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Catabolic Process Protein K63-linked Ubiquitination Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Metabolic Process Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Negative Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Signaling Histone Ubiquitination Histone H2A Ubiquitination Regulation Of Protein Catabolic Process Cell Cycle Histone Monoubiquitination Response To Stress Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Type I Interferon Production Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Programmed Cell Death Cellular Response To Stress Protein K6-linked Ubiquitination Cell Cycle Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Mitotic Cell Cycle
Tagcloud ?		autophagy box catalytic cdk checkpoint complexes cullin1 damage degradation downstream endocytosis f fbxl20 mediates mitotic phosphatidylinositol promote proteasomal provides ptdins3 ptdins3p regulate scf skp1 sorting transduction ubiquitination vacuolar vps34	conjugating cytoprotective degraded extracting govern homeostasis imp import importin keap1 locales localizes mitochondria nrf2 outer p45 partitioning perinuclear prematurely relocalizes repressive restore restrict restricting subcellular tightly transcriptionally unresolved
Tagcloud (Difference) ?		autophagy box catalytic cdk checkpoint complexes cullin1 damage degradation downstream endocytosis f fbxl20 mediates mitotic phosphatidylinositol promote proteasomal provides ptdins3 ptdins3p regulate scf skp1 sorting transduction ubiquitination vacuolar vps34	conjugating cytoprotective degraded extracting govern homeostasis imp import importin keap1 locales localizes mitochondria nrf2 outer p45 partitioning perinuclear prematurely relocalizes repressive restore restrict restricting subcellular tightly transcriptionally unresolved
Tagcloud (Intersection) ?