TRIB1 and ALOX12

Number of citations of the paper that reports this interaction (PMID 10727209)
7

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TRIB1	ALOX12
Gene Name		tribbles pseudokinase 1	arachidonate 12-lipoxygenase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Cytosol Membrane Sarcolemma Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Kinase Inhibitor Activity ATP Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity	Arachidonate 12-lipoxygenase Activity Iron Ion Binding Protein Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hepoxilin-epoxide Hydrolase Activity Hepoxilin A3 Synthase Activity
	Biological Process	Protein Phosphorylation Negative Regulation Of Protein Kinase Activity JNK Cascade Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Lipopolysaccharide Regulation Of MAP Kinase Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Smooth Muscle Cell Proliferation	Movement Of Cell Or Subcellular Component Aging Positive Regulation Of Cell Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process Arachidonic Acid Metabolic Process Lipoxygenase Pathway Fatty Acid Oxidation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Superoxide Anion Generation Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Linoleic Acid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Vasodilation Positive Regulation Of Smooth Muscle Cell Proliferation Hepoxilin Metabolic Process Hepoxilin Biosynthetic Process Positive Regulation Of Mitochondrial Depolarization Establishment Of Skin Barrier Cellular Response To Lipid Reactive Oxygen Species Metabolic Process Negative Regulation Of Platelet Aggregation Leukotriene A4 Metabolic Process Lipoxin Metabolic Process Lipoxin A4 Biosynthetic Process Lipoxin B4 Biosynthetic Process
Pathways			Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of Lipoxins (LX) Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
Drugs
Diseases
GWAS		Adiponectin levels ( 22479202) Cholesterol, total ( 19060911 20686565) HDL cholesterol ( 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) Inflammatory bowel disease ( 23128233) LDL cholesterol ( 20864672 19060911 20686565) Lipid metabolism phenotypes ( 19936222) Liver enzyme levels (alanine transaminase) ( 22001757) Liver enzyme levels (alkaline phosphatase) ( 22001757) Obesity-related traits ( 23251661) Response to statin therapy ( 20339536) Triglycerides ( 18193043 18193044 20864672 19060906 20139978 20686565) Triglycerides-Blood Pressure (TG-BP) ( 21386085)
Protein-Protein Interactions		4 interactors: ALOX12 MAP2K1 MAP2K4 MAP2K7	7 interactors: ITGB4 KAT5 KRT5 KRT85 LMNA PLA2G2A TRIB1
Entrez ID		10221	239
HPRD ID		09863	01066
Ensembl ID		ENSG00000173334	ENSG00000108839
Uniprot IDs		Q96RU8	P18054
PDB IDs			2ABU 3D3L
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Sorbitol Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Stress-activated MAPK Cascade Pathogenesis Positive Regulation Of MAP Kinase Activity Fc-epsilon Receptor Signaling Pathway MAPK Cascade Regulation Of Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Activation Of JUN Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Death Positive Regulation Of Apoptotic Process Cellular Response To Carbohydrate Stimulus Positive Regulation Of Programmed Cell Death	Hemidesmosome Assembly Cell-substrate Junction Assembly Sterol Regulatory Element Binding Protein Import Into Nucleus
Tagcloud ?		05x10 36x10 amd americans arms2 assuming cetp cfh corrections european fundus generalize genomics kctd10 lpl mexican mvk photography powered rs10490924 rs1061170 rs1800775 rs2338104 rs328 rs6987702 singaporeans strict survive uncorrected	agxt aim2 built cpg discriminate discriminated e85 epigenome false il10 jak3 lcn2 leukocyte manifested methqtl obtainable p1075 p180 p220 p348 p624 p817 p86 pac penalized resectable smoker statistic zap70
Tagcloud (Difference) ?		05x10 36x10 amd americans arms2 assuming cetp cfh corrections european fundus generalize genomics kctd10 lpl mexican mvk photography powered rs10490924 rs1061170 rs1800775 rs2338104 rs328 rs6987702 singaporeans strict survive uncorrected	agxt aim2 built cpg discriminate discriminated e85 epigenome false il10 jak3 lcn2 leukocyte manifested methqtl obtainable p1075 p180 p220 p348 p624 p817 p86 pac penalized resectable smoker statistic zap70
Tagcloud (Intersection) ?