ALOX12 and KRT5

Number of citations of the paper that reports this interaction (PMID 10727209)
7

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo)

		ALOX12	KRT5
Gene Name		arachidonate 12-lipoxygenase	keratin 5, type II
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane Sarcolemma Extracellular Vesicular Exosome	Nucleus Cytoplasm Mitochondrion Cytosol Intermediate Filament Plasma Membrane Membrane Keratin Filament Extracellular Vesicular Exosome
	Molecular Function	Arachidonate 12-lipoxygenase Activity Iron Ion Binding Protein Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hepoxilin-epoxide Hydrolase Activity Hepoxilin A3 Synthase Activity	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding
	Biological Process	Movement Of Cell Or Subcellular Component Aging Positive Regulation Of Cell Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process Arachidonic Acid Metabolic Process Lipoxygenase Pathway Fatty Acid Oxidation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Superoxide Anion Generation Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Linoleic Acid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Vasodilation Positive Regulation Of Smooth Muscle Cell Proliferation Hepoxilin Metabolic Process Hepoxilin Biosynthetic Process Positive Regulation Of Mitochondrial Depolarization Establishment Of Skin Barrier Cellular Response To Lipid Reactive Oxygen Species Metabolic Process Negative Regulation Of Platelet Aggregation Leukotriene A4 Metabolic Process Lipoxin Metabolic Process Lipoxin A4 Biosynthetic Process Lipoxin B4 Biosynthetic Process	Epidermis Development Hemidesmosome Assembly Cell Junction Assembly
Pathways		Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of Lipoxins (LX) Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of Hepoxilins (HX) and Trioxilins (TrX)	Cell junction organization Type I hemidesmosome assembly
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ITGB4 KAT5 KRT5 KRT85 LMNA PLA2G2A TRIB1	19 interactors: ALOX12 ALOX12B APC DSP DST EVPL KIFC3 KRT1 KRT14 KRT15 KRT18 KRT31 KRT38 KRT40 PKP2 SUMO1 SUMO2 SUMO3 TCHP
Entrez ID		239	3852
HPRD ID		01066	01010
Ensembl ID		ENSG00000108839	ENSG00000186081
Uniprot IDs		P18054	P13647
PDB IDs		2ABU 3D3L	3TNU
Enriched GO Terms of Interacting Partners?		Hemidesmosome Assembly Cell-substrate Junction Assembly Sterol Regulatory Element Binding Protein Import Into Nucleus	Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Skin Development Epidermis Development Establishment Of Skin Barrier Intermediate Filament Organization Regulation Of Water Loss Via Skin Protein Sumoylation Multicellular Organismal Water Homeostasis Hepoxilin Metabolic Process Hepoxilin Biosynthetic Process Intermediate Filament Bundle Assembly Cell Junction Assembly Water Homeostasis Bundle Of His Cell To Purkinje Myocyte Communication Anatomical Structure Development Cell-cell Junction Organization Positive Regulation Of Protein Catabolic Process Linoleic Acid Metabolic Process Desmosome Organization Hemidesmosome Assembly Lipoxygenase Pathway Developmental Process Positive Regulation Of Proteolysis Epithelium Development Long-chain Fatty Acid Biosynthetic Process Regulation Of Proteolysis Cytoskeleton Organization Ventricular Cardiac Muscle Cell Action Potential Tissue Development Regulation Of Heart Rate By Cardiac Conduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Component Maintenance Positive Regulation Of Cellular Protein Catabolic Process Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Single Organismal Cell-cell Adhesion Apoptotic Process Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Conduction Peptide Cross-linking Programmed Cell Death Cell-substrate Junction Assembly Cell Death Death
Tagcloud ?		agxt aim2 built cpg discriminate discriminated e85 epigenome false il10 jak3 lcn2 leukocyte manifested methqtl obtainable p1075 p180 p220 p348 p624 p817 p86 pac penalized resectable smoker statistic zap70	aldh1 ciliated columnar exposes foxj1 gynaecological hgsc hgscs krt7 layered lef1 mem membraneous nests outgrowths oviduct oviductal oviducts pax2 pseudostratified rcn1 scout scouts stathmin stins tubal walthard wcn wcns
Tagcloud (Difference) ?		agxt aim2 built cpg discriminate discriminated e85 epigenome false il10 jak3 lcn2 leukocyte manifested methqtl obtainable p1075 p180 p220 p348 p624 p817 p86 pac penalized resectable smoker statistic zap70	aldh1 ciliated columnar exposes foxj1 gynaecological hgsc hgscs krt7 layered lef1 mem membraneous nests outgrowths oviduct oviductal oviducts pax2 pseudostratified rcn1 scout scouts stathmin stins tubal walthard wcn wcns
Tagcloud (Intersection) ?