CDK3 and CCNE2

Number of citations of the paper that reports this interaction (PMID 9840943)
26

Data Source:
HPRD (two hybrid)

		CDK3	CCNE2
Gene Name		cyclin-dependent kinase 3	cyclin E2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleoplasm Cytosol
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Mitotic Nuclear Division Cell Proliferation G0 To G1 Transition Cell Division Regulation Of Cell Cycle	Cell Cycle Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Initiation Cell Division
Pathways			DNA Damage/Telomere Stress Induced Senescence Cellular Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes p53-Dependent G1/S DNA damage checkpoint G0 and Early G1 S Phase Cyclin E associated events during G1/S transition Cell Cycle, Mitotic p53-Dependent G1 DNA Damage Response SCF(Skp2)-mediated degradation of p27/p21 G1/S Transition Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G1-G1/S phases G1/S DNA Damage Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: APP CABLES1 CABLES2 CCNA2 CCNC CCNE1 CCNE2 CDC37 CDKN1A CDKN1B CDKN3 E2F1 E2F2 E2F3 KIR3DL1 NEDD4L PPARA RB1	11 interactors: APP CDK2 CDK3 CDKN1A CDKN1B CDKN1C FBXW7 ORC3 SUMO2 SUMO3 ZDHHC17
Entrez ID		1018	9134
HPRD ID		00446	04801
Ensembl ID		ENSG00000250506	ENSG00000175305
Uniprot IDs		Q00526	O96020 Q8WUE3
PDB IDs		1LFN
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Checkpoint Cell Division Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Cell Cycle Process Regulation Of Mitotic Cell Cycle DNA-templated Transcription, Initiation Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Catalytic Activity Positive Regulation Of Transcription, DNA-templated Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Lens Fiber Cell Apoptotic Process Notch Signaling Pathway Regulation Of Gene Expression Cell Cycle Arrest Positive Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Cell Cycle Signaling Negative Regulation Of Mitotic Cell Cycle	G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Process Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Protein Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Protein Catabolic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Protein Kinase Activity Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Cellular Protein Modification Process Regulation Of Kinase Activity Signal Transduction By P53 Class Mediator Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Mitotic Cell Cycle Arrest Negative Regulation Of Epithelial Cell Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Serine/threonine Kinase Activity Cell Cycle Arrest Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Tagcloud ?		3h adenovirus augmented beta brdu cyclin d2 d3 dedifferentiation exit g0 g1 hypothesized incorporation inducing islets ki67 pancreatic prb quiescence quiescent rat recover regeneration replace staining thymidine transduced tunel	amplification amplifications aneuploidy breast carcinomas clinicopathologic coexist december ductal fish foci infiltrating january ki microarray multi myc often overlapping quantitative relationship roles selected showing situ sixty strong unique
Tagcloud (Difference) ?		3h adenovirus augmented beta brdu cyclin d2 d3 dedifferentiation exit g0 g1 hypothesized incorporation inducing islets ki67 pancreatic prb quiescence quiescent rat recover regeneration replace staining thymidine transduced tunel	amplification amplifications aneuploidy breast carcinomas clinicopathologic coexist december ductal fish foci infiltrating january ki microarray multi myc often overlapping quantitative relationship roles selected showing situ sixty strong unique
Tagcloud (Intersection) ?