CDK3 and CDKN3

Number of citations of the paper that reports this interaction (PMID 8242750)
471

Data Source:
HPRD (two hybrid, in vivo)

		CDK3	CDKN3
Gene Name		cyclin-dependent kinase 3	cyclin-dependent kinase inhibitor 3
Image
Gene Ontology Annotations	Cellular Component		Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding	Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Mitotic Nuclear Division Cell Proliferation G0 To G1 Transition Cell Division Regulation Of Cell Cycle	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Cell Proliferation Peptidyl-tyrosine Dephosphorylation
Pathways
Drugs
Diseases
GWAS			Dental caries ( 23259602) Working memory ( 21107309)
Protein-Protein Interactions		18 interactors: APP CABLES1 CABLES2 CCNA2 CCNC CCNE1 CCNE2 CDC37 CDKN1A CDKN1B CDKN3 E2F1 E2F2 E2F3 KIR3DL1 NEDD4L PPARA RB1	7 interactors: CDC25A CDK1 CDK2 CDK3 CEBPA MS4A3 NCOA3
Entrez ID		1018	1033
HPRD ID		00446	00450
Ensembl ID		ENSG00000250506	ENSG00000100526
Uniprot IDs		Q00526	F5H232 Q16667
PDB IDs		1LFN	1FPZ 1FQ1
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Checkpoint Cell Division Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Cell Cycle Process Regulation Of Mitotic Cell Cycle DNA-templated Transcription, Initiation Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Catalytic Activity Positive Regulation Of Transcription, DNA-templated Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Lens Fiber Cell Apoptotic Process Notch Signaling Pathway Regulation Of Gene Expression Cell Cycle Arrest Positive Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Cell Cycle Signaling Negative Regulation Of Mitotic Cell Cycle	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Nuclear Division Regulation Of Cell Cycle Cell Division G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Organelle Organization DNA Replication Histone Phosphorylation Cell Cycle Process Centrosome Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Histone Modification Positive Regulation Of DNA Replication Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Organ Regeneration Response To Inorganic Substance Regulation Of Ubiquitin-protein Transferase Activity Pronuclear Fusion Cell Cycle Mitotic DNA Damage Checkpoint Centrosome Organization Mitotic DNA Integrity Checkpoint Cellular Response To Reactive Oxygen Species Microtubule Organizing Center Organization Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Placenta Development Positive Regulation Of Gene Expression Chromatin Modification Regulation Of DNA Replication G0 To G1 Transition Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Inorganic Substance Cellular Protein Modification Process Positive Regulation Of DNA Metabolic Process DNA Damage Checkpoint Chromatin Organization Mitotic Cell Cycle Checkpoint Response To Vitamin B2 Positive Regulation Of DNA-dependent DNA Replication Initiation Cellular Macromolecule Biosynthetic Process Placenta Development Response To Reactive Oxygen Species Receptor Transactivation Macromolecule Biosynthetic Process Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination
Tagcloud ?		3h adenovirus augmented beta brdu cyclin d2 d3 dedifferentiation exit g0 g1 hypothesized incorporation inducing islets ki67 pancreatic prb quiescence quiescent rat recover regeneration replace staining thymidine transduced tunel	aberrantly anaplastic atc atcs axin1 braf cdki cdkn1a cdkn1b cdkn2a cdkn2b cdkn2c ctnnb1 exclusivity ink4b ink4c mutational mutual p14 p15 p18 pdtc pdtcs pik3ca profiled snai2 spliced spot underexpression
Tagcloud (Difference) ?		3h adenovirus augmented beta brdu cyclin d2 d3 dedifferentiation exit g0 g1 hypothesized incorporation inducing islets ki67 pancreatic prb quiescence quiescent rat recover regeneration replace staining thymidine transduced tunel	aberrantly anaplastic atc atcs axin1 braf cdki cdkn1a cdkn1b cdkn2a cdkn2b cdkn2c ctnnb1 exclusivity ink4b ink4c mutational mutual p14 p15 p18 pdtc pdtcs pik3ca profiled snai2 spliced spot underexpression
Tagcloud (Intersection) ?