RNF41 - Wiki-CORONA

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ADRB2	adrenoceptor beta 2	Adrenoceptors G alpha (s) signalling events Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis ADORA2B mediated anti-inflammatory cytokines production	Spermine Amphetamine Betaxolol Bethanidine Isoetarine Cabergoline Metoprolol Amitriptyline Olanzapine Atenolol Norepinephrine Mirtazapine Timolol Phenylpropanolamine Dipivefrin Sotalol Carteolol Nortriptyline Propranolol Labetalol Bisoprolol Epinephrine Trimipramine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Isoprenaline Arbutamine Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra Mephentermine Procaterol Clenbuterol Bambuterol Oxprenolol Putrescine Spermidine Celiprolol Nebivolol Indacaterol NCX 950 Asenapine Droxidopa Bufuralol (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol Bopindolol Bupranolol Befunolol Olodaterol Vilanterol Tulobuterol Levosalbutamol	Asthma
AP2S1	adaptor related protein complex 2 subunit sigma 1	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance
APP	amyloid beta precursor protein	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Phenserine Tiomolibdate ion CAD106 Mito-4509 Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F)	Alzheimer's disease (AD)
ARL6IP4	ADP ribosylation factor like GTPase 6 interacting protein 4
ASB6	ankyrin repeat and SOCS box containing 6	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
BIRC6	baculoviral IAP repeat containing 6
C1orf109	chromosome 1 open reading frame 109
ERBB3	erb-b2 receptor tyrosine kinase 3			Lethal congenital contractural syndrome (LCCS) Type I diabetes mellitus
ERBB4	erb-b2 receptor tyrosine kinase 4		Afatinib Brigatinib
GDF11	growth differentiation factor 11
IRS4	insulin receptor substrate 4	IRS-related events triggered by IGF1R
ISCA2	iron-sulfur cluster assembly 2	Mitochondrial iron-sulfur cluster biogenesis
KDM3B	lysine demethylase 3B	HDMs demethylate histones
LEPR	leptin receptor		Leptin Metreleptin
LZTS2	leucine zipper tumor suppressor 2
MAGEL2	MAGE family member L2
MARK2	microtubule affinity regulating kinase 2
MNAT1	MNAT1 component of CDK activating kinase	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs
MTNR1A	melatonin receptor 1A	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
MTNR1B	melatonin receptor 1B	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon	Type II diabetes mellitus
NEUROD4	neuronal differentiation 4
ORMDL2	ORMDL sphingolipid biosynthesis regulator 2	Sphingolipid de novo biosynthesis
PPP1R1A	protein phosphatase 1 regulatory inhibitor subunit 1A
RFC4	replication factor C subunit 4	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint
RNF166	ring finger protein 166
RRM2B	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes	Cladribine	Mitochondrial DNA depletion syndrome (MDS)
SUOX	sulfite oxidase	Sulfide oxidation to sulfate	(Molybdopterin-S,S)-Dioxo-Thio-Molybdenum(V)
TBATA	thymus, brain and testes associated
TRIM32	tripartite motif containing 32	Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation		Bardet-Biedl syndrome (BBS)
TRIM8	tripartite motif containing 8	Interferon gamma signaling
TSG101	tumor susceptibility 101	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
UBASH3A	ubiquitin associated and SH3 domain containing A
UBASH3B	ubiquitin associated and SH3 domain containing B
UBE2D3	ubiquitin conjugating enzyme E2 D3	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Antigen processing: Ubiquitination & Proteasome degradation
UBE2K	ubiquitin conjugating enzyme E2 K	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
UBE2U	ubiquitin conjugating enzyme E2 U	Antigen processing: Ubiquitination & Proteasome degradation
UBE2Z	ubiquitin conjugating enzyme E2 Z	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
USP8	ubiquitin specific peptidase 8	Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity
ZAP70	zeta chain of T cell receptor associated protein kinase 70	Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules	Staurosporine	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency

Search Results for: RNF41