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Search Results for: F2RL1

21 interactions involving F2RL1 - F2R like trypsin receptor 1 found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
ANKRA2 ankyrin repeat family A member 2
CAPN1 calpain 1
  • Degradation of the extracellular matrix
  • Degradation of the extracellular matrix
  • Neutrophil degranulation
  • Formation of the cornified envelope
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • N-[N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-Butyl]-Guanidine
  • CBZ-LEU-LEU-TYR-CH2F
  • (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
CAPN2 calpain 2
  • Degradation of the extracellular matrix
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
CBL Cbl proto-oncogene
  • Interleukin-6 signaling
  • Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
  • Spry regulation of FGF signaling
  • Regulation of KIT signaling
  • EGFR downregulation
  • TGF-beta receptor signaling activates SMADs
  • Constitutive Signaling by EGFRvIII
  • Negative regulation of FGFR1 signaling
  • Negative regulation of FGFR2 signaling
  • Negative regulation of FGFR3 signaling
  • Negative regulation of FGFR4 signaling
  • Negative regulation of MET activity
  • PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • InlB-mediated entry of Listeria monocytogenes into host cell
  • InlB-mediated entry of Listeria monocytogenes into host cell
  • Regulation of signaling by CBL
  • Regulation of signaling by CBL
  • Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
COPS5 COP9 signalosome subunit 5
  • DNA Damage Recognition in GG-NER
  • Formation of TC-NER Pre-Incision Complex
  • Cargo recognition for clathrin-mediated endocytosis
  • Neddylation
CTSG cathepsin G
  • Degradation of the extracellular matrix
  • Activation of Matrix Metalloproteinases
  • Metabolism of Angiotensinogen to Angiotensins
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Interleukin-1 processing
  • Neutrophil degranulation
  • Antimicrobial peptides
  • Suppression of apoptosis
  • Purinergic signaling in leishmaniasis infection
  • Bis-Napthyl Beta-Ketophosphonic Acid
  • 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid
CYFIP2 cytoplasmic FMR1 interacting protein 2
  • Regulation of actin dynamics for phagocytic cup formation
  • Regulation of actin dynamics for phagocytic cup formation
  • VEGFA-VEGFR2 Pathway
  • RHO GTPases Activate WASPs and WAVEs
  • RHO GTPases Activate WASPs and WAVEs
  • FCGR3A-mediated phagocytosis
  • FCGR3A-mediated phagocytosis
DNMT3L DNA methyltransferase 3 like
  • DNA methylation
ELANE elastase, neutrophil expressed
  • Collagen degradation
  • Degradation of the extracellular matrix
  • Degradation of the extracellular matrix
  • Activation of Matrix Metalloproteinases
  • Neutrophil degranulation
  • Antimicrobial peptides
  • Regulation of Complement cascade
  • Pegfilgrastim
  • Alpha-1-proteinase inhibitor
  • Filgrastim
  • Mdl 101,146
  • Freselestat
  • Elafin
  • Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
F2 coagulation factor II, thrombin
  • Intrinsic Pathway of Fibrin Clot Formation
  • Common Pathway of Fibrin Clot Formation
  • Gamma-carboxylation of protein precursors
  • Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
  • Removal of aminoterminal propeptides from gamma-carboxylated proteins
  • Cell surface interactions at the vascular wall
  • Peptide ligand-binding receptors
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • G alpha (q) signalling events
  • Thrombin signalling through proteinase activated receptors (PARs)
  • Platelet Aggregation (Plug Formation)
  • Regulation of Complement cascade
  • Lepirudin
  • Bivalirudin
  • Drotrecogin alfa
  • Coagulation Factor IX (Recombinant)
  • Menadione
  • Argatroban
  • Proflavine
  • Zinc
  • 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide
  • Beta-(2-Naphthyl)-Alanine
  • Hemi-Babim
  • 2-(2-Hydroxy-Phenyl)-3h-Benzoimidazole-5-Carboxamidine
  • 4-Oxo-2-Phenylmethanesulfonyl-Octahydro-Pyrrolo[1,2-a]Pyrazine-6-Carboxylic Acid [1-(N-Hydroxycarbamimidoyl)-Piperidin-4-Ylmethyl]-Amide
  • 4-Iodobenzo[B]Thiophene-2-Carboxamidine
  • CRA_8696
  • Gamma-Carboxy-Glutamic Acid
  • 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
  • Lysophosphotidylserine
  • N-{2,2-DIFLUORO-2-[(2R)-PIPERIDIN-2-YL]ETHYL}-2-[2-(1H-1,2,4-TRIAZOL-1-YL)BENZYL][1,3]OXAZOLO[4,5-C]PYRIDIN-4-AMINE
  • TRANS-4-(GUANIDINOMETHYL)-CYCLOHEXANE-L-YL-D-3-CYCLOHEXYLALANYL-L-AZETIDINE-2-YL-D-TYROSINYL-L-HOMOARGININAMIDE
  • 2-(3-CHLORO-6-{[2,2-DIFLUORO-2-(1-OXIDOPYRIDIN-2-YL)ETHYL]AMINO}-1-OXIDOPYRIDIN-2-YL)-N-[1-(3-CHLOROPHENYL)ETHYL]ACETAMIDE
  • 1-GUANIDINO-4-(N-NITRO-BENZOYLAMINO-L-LEUCYL-L-PROLYLAMINO)BUTANE
  • 1-GUANIDINO-4-(N-PHENYLMETHANESULFONYL-L-LEUCYL-L-PROLYLAMINO)BUTANE
  • Suramin
  • Ximelagatran
  • Thrombomodulin Alfa
  • Human C1-esterase inhibitor
  • Dabigatran etexilate
  • methyl L-phenylalaninate
  • D-phenylalanyl-N-[(1S)-4-{[amino(iminio)methyl]amino}-1-(chloroacetyl)butyl]-L-prolinamide
  • (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide
  • (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamide
  • N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide
  • N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide
  • N-ALLYL-5-AMIDINOAMINOOXY-PROPYLOXY-3-CHLORO-N-CYCLOPENTYLBENZAMIDE
  • 6-(2-HYDROXY-CYCLOPENTYL)-7-OXO-HEPTANAMIDINE
  • 6-CARBAMIMIDOYL-2-[2-HYDROXY-6-(4-HYDROXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACID
  • 6-CARBAMIMIDOYL-2-[2-HYDROXY-5-(3-METHOXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACID
  • N-(3-chlorobenzyl)-1-(4-methylpentanoyl)-L-prolinamide
  • 1-[2-AMINO-2-CYCLOHEXYL-ACETYL]-PYRROLIDINE-3-CARBOXYLIC ACID 5-CHLORO-2-(2-ETHYLCARBAMOYL-ETHOXY)-BENZYLAMIDE
  • 1-[(2R)-2-aminobutanoyl]-N-(3-chlorobenzyl)-L-prolinamide
  • D-leucyl-N-(3-chlorobenzyl)-L-prolinamide
  • D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamide
  • 1-butanoyl-N-(4-carbamimidoylbenzyl)-L-prolinamide
  • N-(4-carbamimidoylbenzyl)-1-(4-methylpentanoyl)-L-prolinamide
  • N-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-L-prolinamide
  • 1-[(2R)-2-aminobutanoyl]-N-(4-carbamimidoylbenzyl)-L-prolinamide
  • D-leucyl-N-(4-carbamimidoylbenzyl)-L-prolinamide
  • D-phenylalanyl-N-{4-[amino(iminio)methyl]benzyl}-L-prolinamide
  • (3R)-8-(dioxidosulfanyl)-3-methyl-1,2,3,4-tetrahydroquinoline
  • D-phenylalanyl-N-(3-fluorobenzyl)-L-prolinamide
  • beta-phenyl-D-phenylalanyl-N-propyl-L-prolinamide
  • (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamide
  • (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamide
  • (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide
  • 2-[2-(4-CHLORO-PHENYLSULFANYL)-ACETYLAMINO]-3-(4-GUANIDINO-PHENYL)-PROPIONAMIDE
  • N4-(N,N-DIPHENYLCARBAMOYL)-AMINOGUANIDINE
  • N7-BUTYL-N2-(5-CHLORO-2-METHYLPHENYL)-5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-2,7-DIAMINE
  • (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide
  • D-phenylalanyl-N-(3-methylbenzyl)-L-prolinamide
  • D-phenylalanyl-N-benzyl-L-prolinamide
  • N-(5-CHLORO-BENZO[B]THIOPHEN-3-YLMETHYL)-2-[6-CHLORO-OXO-3-(2-PYRIDIN-2-YL-ETHYLAMINO)-2H-PYRAZIN-1-YL]-ACETAMIDE
  • 3-cyclohexyl-D-alanyl-N-(3-chlorobenzyl)-L-prolinamide
  • (2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE
  • 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE
  • 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHENESULFONAMIDE
  • N-ETHYL-N-ISOPROPYL-3-METHYL-5-{[(2S)-2-(PYRIDIN-4-YLAMINO)PROPYL]OXY}BENZAMIDE
  • 4-(2,5-DIAMINO-5-HYDROXY-PENTYL)-PHENOL
  • 2-[N'-(4-AMINO-BUTYL)-HYDRAZINOCARBONYL]-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER
  • 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)
  • 1-ETHOXYCARBONYL-D-PHE-PRO-2(4-AMINOBUTYL)HYDRAZINE
  • 4-TERT-BUTYLBENZENESULFONIC ACID
  • 3-AMINO-3-BENZYL-9-CARBOXAMIDE[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE
  • 4-(5-BENZENESULFONYLAMINO-1-METHYL-1H-BENZOIMIDAZOL-2-YLMETHYL)-BENZAMIDINE
  • 1-(2-{[(6-AMINO-2-METHYLPYRIDIN-3-YL)METHYL]AMINO}ETHYL)-6-CHLORO-3-[(2,2-DIFLUORO-2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL
  • 6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL
  • N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]NAPHTHALENE-2-SULFONAMIDE
  • N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONAMIDE
  • 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-6-PYRIDINYL)METHYL]ACETAMIDE
  • 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-3-METHYL-6-PYRIDINYL)METHYL]ACETAMIDE
  • 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDO-2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUOROPHENYL)METHYL]ACETAMIDE
  • 3-(7-DIAMINOMETHYL-NAPHTHALEN-2-YL)-PROPIONIC ACID ETHYL ESTER
  • AC-(D)PHE-PRO-BOROLYS-OH
  • AC-(D)PHE-PRO-BOROHOMOLYS-OH
  • AC-(D)PHE-PRO-BOROHOMOORNITHINE-OH
  • N-[2-(carbamimidamidooxy)ethyl]-2-{6-cyano-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-fluorophenyl}acetamide
  • 3-(4-HYDROXY-PHENYL)PYRUVIC ACID
  • 4-(1R,3AS,4R,8AS,8BR)-[1-DIFLUOROMETHYL-2-(4-FLUOROBENZYL)-3-OXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZAMIDINE
  • (3ASR,4RS,8ASR,8BRS)-4-(2-(4-FLUOROBENZYL)-1,3-DIOXODEACAHYDROPYRROLO[3,4-A] PYRROLIZIN-4-YL)BENZAMIDINE
  • HYL)BENZENECARBOXIMIDAMIDE
  • 1-(HYDROXYMETHYLENEAMINO)-8-HYDROXY-OCTANE
  • [[CYCLOHEXANESULFONYL-GLYCYL]-3[PYRIDIN-4-YL-AMINOMETHYL]ALANYL]PIPERIDINE
  • N-{3-METHYL-5-[2-(PYRIDIN-4-YLAMINO)-ETHOXY]-PHENYL}-BENZENESULFONAMIDE
  • N-[2-({[amino(imino)methyl]amino}oxy)ethyl]-2-{6-chloro-3-[(2,2-difluoro-2-phenylethyl)amino]-2-fluorophenyl}acetamide
  • 4-[3-(4-CHLOROPHENYL)-1H-PYRAZOL-5-YL]PIPERIDINE
  • 3-(4-CHLOROPHENYL)-5-(METHYLTHIO)-4H-1,2,4-TRIAZOLE
  • {(2S)-1-[N-(tert-butoxycarbonyl)glycyl]pyrrolidin-2-yl}methyl (3-chlorophenyl)acetate
  • METHYL-PHE-PRO-AMINO-CYCLOHEXYLGLYCINE
  • 2-NAPHTHALENESULFONIC ACID
  • [PHENYLALANINYL-PROLINYL]-[2-(PYRIDIN-4-YLAMINO)-ETHYL]-AMINE
  • 4-[(3AS,4R,7R,8AS,8BR)-2-(1,3-BENZODIOXOL-5-YLMETHYL)-7-HYDROXY-1,3-DIOXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZENECARBOXIMIDAMIDE
  • BENZOTHIAZOLE
  • Copper
  • Conestat alfa
  • Antithrombin Alfa
  • Nafamostat
  • Gabexate
  • Anti-inhibitor coagulant complex
  • Coagulation Factor IX Human
  • Inherited thrombophilia
F2R coagulation factor II thrombin receptor
  • Common Pathway of Fibrin Clot Formation
  • Peptide ligand-binding receptors
  • G alpha (q) signalling events
  • Thrombin signalling through proteinase activated receptors (PARs)
  • Thrombin signalling through proteinase activated receptors (PARs)
  • Streptokinase
  • SR-123781A
  • Vorapaxar
  • Thrombin
GPRASP1 G protein-coupled receptor associated sorting protein 1
JMY junction mediating and regulatory protein, p53 cofactor
  • Regulation of TP53 Activity through Methylation
LMNA lamin A/C
  • XBP1(S) activates chaperone genes
  • Signaling by BRAF and RAF fusions
  • Restrictive dermopathy
  • Emery-Dreifuss muscular dystrophy
  • Dilated cardiomyopathy (DCM)
  • Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
  • Mandibuloacral dysplasia
  • Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
  • Limb-girdle muscular dystrophy (LGMD)
  • Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
  • Hutchinson-Gilford progeria syndrome
MAP1B microtubule associated protein 1B
NUMA1 nuclear mitotic apparatus protein 1
  • Recruitment of NuMA to mitotic centrosomes
  • Mitotic Prophase
PCBD2 pterin-4 alpha-carbinolamine dehydratase 2
PLG plasminogen
  • Platelet degranulation
  • Degradation of the extracellular matrix
  • Degradation of the extracellular matrix
  • Activation of Matrix Metalloproteinases
  • Signaling by PDGF
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Dissolution of Fibrin Clot
  • Alteplase
  • Urokinase
  • Reteplase
  • Anistreplase
  • Tenecteplase
  • Streptokinase
  • Tranexamic Acid
  • Aminocaproic Acid
  • Bicine
  • Desmoteplase
  • Aprotinin
  • Copper
  • Gabexate
  • Inherited thrombophilia
PRTN3 proteinase 3
  • Common Pathway of Fibrin Clot Formation
  • Other interleukin signaling
  • Neutrophil degranulation
  • Antimicrobial peptides
  • Elafin
RAD17 RAD17 checkpoint clamp loader component
  • Activation of ATR in response to replication stress
  • HDR through Single Strand Annealing (SSA)
  • Processing of DNA double-strand break ends
  • Presynaptic phase of homologous DNA pairing and strand exchange
  • Regulation of TP53 Activity through Phosphorylation
  • G2/M DNA damage checkpoint
ST14 suppression of tumorigenicity 14
  • Formation of the cornified envelope
  • Formation of the cornified envelope
  • Urokinase
  • Benzamidine
  • Ichthyosis with hypotrichosis