G3BP2 and AGO4

		G3BP2	AGO4
Description		G3BP stress granule assembly factor 2	argonaute RISC component 4
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex	P-body Nucleus Cytoplasm Cytosol Membrane RISC Complex RISC-loading Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding Receptor Signaling Complex Scaffold Activity	Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding MiRNA Binding
	Biological Process	Cytoplasmic Sequestering Of NF-kappaB Ras Protein Signal Transduction Positive Regulation Of Signal Transduction Viral Process Stress Granule Assembly Innate Immune Response MRNA Transport Protein Homooligomerization Positive Regulation Of Stress Granule Assembly	MRNA Catabolic Process Synaptonemal Complex Assembly Male Meiotic Nuclear Division Wnt Signaling Pathway, Calcium Modulating Pathway Male Gonad Development RNA Secondary Structure Unwinding MiRNA Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Cell Morphogenesis Pre-miRNA Processing Posttranscriptional Gene Silencing By RNA Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation MRNA Cleavage Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Negative Regulation Of Apoptotic Process Regulation Of Megakaryocyte Differentiation MRNA Cleavage Involved In Gene Silencing By SiRNA
Pathways			Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Subjective response to lithium treatment in bipolar disorder ( 26503763) Testicular germ cell tumor ( 28604728)
Interacting Genes		9 interacting genes: AGO4 CDKL2 MDM2 NFKB1 NFKBIA PHACTR2 PIN1 SDAD1 USO1	5 interacting genes: APP G3BP2 TNRC6A TNRC6B TNRC6C
Entrez ID		9908	192670
HPRD ID		06570	09559
Ensembl ID		ENSG00000138757	ENSG00000134698
Uniprot IDs		A0A024RDB2 A0A024RDE5 Q9UN86	Q9HCK5
PDB IDs		5DRV	6OON
Enriched GO Terms of Interacting Partners?
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