CDC5L and KANSL1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
168

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CDC5L	KANSL1
Description		cell division cycle 5 like	KAT8 regulatory NSL complex subunit 1
Image
GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Membrane Nuclear Speck Perinuclear Region Of Cytoplasm U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Histone Acetyltransferase Complex Condensed Chromosome Kinetochore Nucleus Nucleoplasm NSL Complex MLL1 Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding RNA Binding Protein Binding Protein Phosphatase 1 Binding Protein Kinase Binding Leucine Zipper Domain Binding WD40-repeat Domain Binding	Protein Binding Histone Acetyltransferase Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Mitotic Cell Cycle MRNA Splicing, Via Spliceosome DNA Repair Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Interleukin-2 Signal Transduction Involved In DNA Damage Checkpoint Cellular Response To Wortmannin Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Prolactin	Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation
Pathways		mRNA Splicing - Major Pathway	HATs acetylate histones
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Chin dimples ( 27182965) FEV1 ( 30804560) Height ( 28552196) Ischemic stroke ( 26089329) Lung function (FVC) ( 30804560) Male-pattern baldness ( 27182965) Monobrow ( 27182965) Nose morphology ( 29921221) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Osteoarthritis ( 22763110) Osteoarthritis of the hand ( 28855172) Stroke (ischemic) ( 22941190)	Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Automobile speeding propensity ( 30643258) Breast cancer ( 29059683) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive function ( 28093568) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) General factor of neuroticism ( 30867560) Hand grip strength ( 29313844) Handedness (Left-handed vs. non-left-handed) ( 30980028) Handedness (Right-handed vs. non-right-handed) ( 30980028) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income ( 31844048) Idiopathic pulmonary fibrosis ( 24429156) Lung function (FEV1) ( 28166213) Lung function (FVC) ( 28166213) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte percentage of white cells ( 27863252) Macular thickness ( 30535121) Male-pattern baldness ( 27182965 28196072) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Neuroticism ( 29255261) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Parkinson's disease ( 31660654 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pulse pressure ( 27841878) Reaction time ( 29844566) Red blood cell count ( 29403010) Red cell distribution width ( 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Risk-taking tendency (4-domain principal component model) ( 30643258) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878) Ventral diencephalon volume ( 31530798)
Interacting Genes		69 interacting genes: AKAP6 AKAP9 BCAS2 BICRAL CALM1 CCDC136 CDK2 CDKN1A CDKN2A CDT1 CTNNBL1 DISC1 DIXDC1 DST EMID1 ERG EXOC1 EXOC7 GOLGA2 GOLGA8EP GOLGA8F GRB14 GSE1 HNRNPM HOOK1 KALRN KANSL1 KDM1A KIF3C KIF5B KRT18 LMO2 MACF1 MCM10 MCM3 MCM4 MCM5 MELK MYT1L ORC1 ORC2 ORC5 PCBD2 PDE4DIP PLRG1 PPFIA2 PPP1CA PPP1R13B PPP1R8 PRPF3 RPA1 RPA2 RPA3 SFR1 SH3BP5 SMARCD1 SPTBN1 SYNE1 TRAF3IP1 TRAK1 TRIO TTF2 WWC1 YWHAG YWHAQ YWHAZ ZNF35 ZNF451 ZSCAN1	35 interacting genes: CALCOCO2 CCDC136 CCDC85B CDC5L CDR2 CEP70 DISC1 DTNBP1 EXOC1 FSD2 GOLGA2 HOOK2 HSPB1 KAT8 KDM1A KIFC3 KRT15 MAGEA12 MDFI NECAB2 NINL NUP62 NUTM1 PLEKHA5 PNMA1 PSME3 RETREG3 SMAD3 SPAG5 TFIP11 TRAF2 TRAF4 TRIM27 USHBP1 WDR5
Entrez ID		988	284058
HPRD ID		04184	11254
Ensembl ID		ENSG00000096401	ENSG00000120071
Uniprot IDs		Q99459	A0A024R9Y2 A0A1W2PRB5 Q7Z3B3
PDB IDs		2DIM 2DIN 5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV	4CY1 4CY2
Enriched GO Terms of Interacting Partners?
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