SNX17 and VLDLR

Number of citations of the paper that reports this interaction (PubMedID 12169628)
42

Data Source:
HPRD (in vitro, in vivo)

		SNX17	VLDLR
Description		sorting nexin 17	very low density lipoprotein receptor
Image
GO Annotations	Cellular Component	Endosome Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Intracellular Membrane-bounded Organelle	Lysosomal Membrane Plasma Membrane Clathrin-coated Pit Membrane Integral Component Of Membrane Very-low-density Lipoprotein Particle Receptor Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Protein C-terminus Binding Phosphatidylinositol Binding Low-density Lipoprotein Particle Receptor Binding	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Cargo Receptor Activity Reelin Receptor Activity Calcium-dependent Protein Binding
	Biological Process	Cardiac Septum Development Cholesterol Catabolic Process Intracellular Protein Transport Receptor-mediated Endocytosis Signal Transduction Endosomal Transport Regulation Of Endocytosis Endocytic Recycling Aorta Development Coronary Vasculature Development Retrograde Transport, Endosome To Plasma Membrane	Lipid Transport Receptor-mediated Endocytosis Signal Transduction Nervous System Development Axon Guidance Memory Cholesterol Metabolic Process Ventral Spinal Cord Development Low-density Lipoprotein Particle Receptor Catabolic Process Glycoprotein Transport Very-low-density Lipoprotein Particle Clearance Reelin-mediated Signaling Pathway Positive Regulation Of Protein Kinase Activity Dendrite Morphogenesis Positive Regulation Of Dendrite Development
Pathways			Reelin signalling pathway VLDLR internalisation and degradation VLDL clearance
Drugs			Lauric Acid
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Crohn's disease ( 28067908) High light scatter reticulocyte count ( 27863252) Inflammatory bowel disease ( 28067908) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Microalbuminuria ( 31511532) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378 31511532) Urinary sodium to potassium ratio ( 30910378)	Alzheimer's disease (age of onset) ( 22005931) Cholesterol, total ( 24097068) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Gambling ( 22780124) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 28334899) Systolic blood pressure ( 26969751) Total cholesterol levels ( 30275531) Vascular endothelial growth factor levels ( 26910538 27989323 31217265 21757650) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		11 interacting genes: ANXA2 APP HRAS LDLR LRP1 LRP2 LRP8 RLIM SELP SKIL VLDLR	9 interacting genes: APOE CD36 CLU DAB1 LPL LRPAP1 MYLIP RELN SNX17
Entrez ID		9784	7436
HPRD ID		05812	01895
Ensembl ID		ENSG00000115234	ENSG00000147852
Uniprot IDs		B4DDM3 B4DQ37 B4DTB8 Q15036	P98155 Q5VVF5
PDB IDs		3FOG 3LUI 4GXB 4TKN	1V9U 3DPR 6BYV
Enriched GO Terms of Interacting Partners?
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