GDF15 and MDFI

Number of citations of the paper that reports this interaction (PubMedID 19060904)
283

Data Source:
BioGRID (two hybrid)

		GDF15	MDFI
Description		growth differentiation factor 15	MyoD family inhibitor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleus Cytoplasm
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity	Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	Activation Of MAPK Activity Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion	Negative Regulation Of Transcription By RNA Polymerase II Dorsal/ventral Axis Specification Negative Regulation Of Wnt Signaling Pathway Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA Binding Embryonic Skeletal System Morphogenesis Trophoblast Giant Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)	Grapefruit juice consumption ( 31046077) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)
Interacting Genes		16 interacting genes: ALOX5AP BORCS8-MEF2B C19orf57 COPE EHF FCHO1 HOMER3 IL27RA MAPK14 MAST3 MDFI MED26 NLGN3 PDE4C SIN3B SULT2A1	243 interacting genes: AANAT AASDHPPT ABCF3 ABHD17A ADAMTSL3 AKAP17A AP5Z1 APLN AQP1 AQP5 ARHGAP32 ARID5A ATG12 ATN1 ATP6V0C ATXN7L2 AVPI1 AXIN1 B3GNT9 BAALC BAHD1 BANP BBS2 BCL6 BEX1 C10orf62 C22orf39 C8orf33 C8orf48 CATSPER1 CBFA2T2 CBX2 CC2D1B CCDC116 CCDC120 CCDC185 CCDC198 CCDC33 CCER1 CDC42EP1 CDCA7L CDKL3 CEP57L1 CFAP206 CHIC2 CHRNG CLPB CNNM3 CREB5 CRX CRY1 CSNK1G2-AS1 CXCL16 CYBA DAAM2 DBF4B DCAF8 DCANP1 DDX19A DHRS1 DKK1 DMRT3 DNPEP DOCK2 DUSP6 EBI3 EIF4A2 EIF4E2 ELOA ENKD1 ETNK2 EWSR1 FAAP100 FAM124B FAM161A FAM27E3 FASTK FBXL18 FBXO34 FBXW5 FES FNDC11 FOXD4L6 FZD9 GATA1 GATA2 GDF15 GLIDR GLRX3 GNAI2 GNG5 GPATCH2L GPRIN2 GTF3C5 HEYL HNRNPLL HOXA1 HOXB9 HTR1B ILF3 INTS11 IQUB KANSL1 KAT5 KIAA0040 KIAA0408 KIF1A KPNA2 KRAS LAMB3 LASP1 LCE1B LCE3E LCE4A LIMS2 LINC00636 LINC01588 LMO3 LRCH4 LRRN4 MACIR MAGED1 MAGEF1 MAPKBP1 MCM5 MEOX2 METTL17 MFSD3 MGAT5B MRPL20-AS1 MVP MYF5 MYOD1 MYOG NAB2 NDUFA7 NECTIN2 NEU4 NOL4L-DT NPDC1 NR1H2 NR1H3 NTAQ1 ODAPH OLIG3 OTX1 PARP11 PBXIP1 PDGFB PDIA5 PGLS PHLDA1 PID1 PIDD1 PIH1D2 PIN1 PLEKHG4 POM121L8P PRKAB2 PRPF31 PTPMT1 RABL6 REG3A REX1BD RFX2 RIPPLY1 RNF6 RTP5 SERF2 SFI1 SHFL SIX1 SLC25A10 SLC35A2 SLC9A1 SPATA3 SPATA8 SPG7 SPRY1 SPRY2 TAP1 TCF3 TEAD4 TGIF1 THAP7 THEG TIE1 TINAGL1 TMEM241 TNNI1 TNP2 TRAF3IP2 TRIB3 TRPC1 TRPV6 TSC2 TTC23 TTC25 TTLL10 TUSC2 TYMSOS TYRO3 USP20 USP6 VHL VPS72 WDFY3 WNT11 ZBTB24 ZBTB25 ZBTB9 ZFYVE26 ZNF101 ZNF124 ZNF136 ZNF138 ZNF155 ZNF205 ZNF223 ZNF230 ZNF264 ZNF266 ZNF408 ZNF417 ZNF426 ZNF433 ZNF439 ZNF440 ZNF490 ZNF559 ZNF564 ZNF578 ZNF581 ZNF587 ZNF607 ZNF646 ZNF670 ZNF679 ZNF688 ZNF707 ZNF764 ZNF79 ZNF844
Entrez ID		9518	4188
HPRD ID		05608	07280
Ensembl ID		ENSG00000130513	ENSG00000112559
Uniprot IDs		Q99988	A0A024RCY2 B1AKB6 Q99750
PDB IDs		5VT2 5VZ3 5VZ4 6Q2J
Enriched GO Terms of Interacting Partners?
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