GDF15 and COPE

		GDF15	COPE
Description		growth differentiation factor 15	COPI coat complex subunit epsilon
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome	Golgi Membrane Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol COPI Vesicle Coat Transport Vesicle
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity	Structural Molecule Activity Protein Binding
	Biological Process	Activation Of MAPK Activity Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion	ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Intra-Golgi Vesicle-mediated Transport Protein Transport
Pathways			COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		16 interacting genes: ALOX5AP BORCS8-MEF2B C19orf57 COPE EHF FCHO1 HOMER3 IL27RA MAPK14 MAST3 MDFI MED26 NLGN3 PDE4C SIN3B SULT2A1	12 interacting genes: ARF1 COPA COPB1 COPB2 COPG1 COPG2 EFHC2 GDF15 RCHY1 SCYL1 TMED10 WBP2
Entrez ID		9518	11316
HPRD ID		05608	06089
Ensembl ID		ENSG00000130513	ENSG00000105669
Uniprot IDs		Q99988	M0QXB4 O14579
PDB IDs		5VT2 5VZ3 5VZ4 6Q2J	6TZT 6U3V
Enriched GO Terms of Interacting Partners?
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