VAPA and OSBP

Number of citations of the paper that reports this interaction (PubMedID 12023275)
74

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		VAPA	OSBP
Description		VAMP associated protein A	oxysterol binding protein
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Bicellular Tight Junction Microtubule Cytoskeleton Integral Component Of Membrane Nuclear Membrane Vesicle Azurophil Granule Membrane Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Membrane Cell Junction Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Cadherin Binding Protein Heterodimerization Activity	Protein Binding Oxysterol Binding Lipid Binding Sterol Transporter Activity Protein Domain Specific Binding Sterol Binding Phosphatidylinositol-4-phosphate Binding Intermembrane Sterol Transfer Activity
	Biological Process	ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Cell Death Viral Process Sphingolipid Biosynthetic Process Neuron Projection Development Protein Folding In Endoplasmic Reticulum Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Membrane Fusion Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding	Bile Acid Biosynthetic Process Sterol Transport Intracellular Cholesterol Transport
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Sphingolipid de novo biosynthesis Synthesis of bile acids and bile salts
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Peak expiratory flow ( 30804560) Pulmonary function (smoking interaction) ( 23284291)
Interacting Genes		15 interacting genes: ADGRG7 ADRB2 APOD APP CACNG1 EGFR KCNB1 NSF OPRM1 OSBP RMDN3 SIK1 VAMP1 VAMP2 ZBTB22	3 interacting genes: CSNK2A1 MARK2 VAPA
Entrez ID		9218	5007
HPRD ID		09299	01327
Ensembl ID		ENSG00000101558	ENSG00000110048
Uniprot IDs		Q9P0L0	P22059
PDB IDs		2RR3	2RR3
Enriched GO Terms of Interacting Partners?
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