DDX21 and TET1

		DDX21	TET1
Description		DExD-box helicase 21	tet methylcytosine dioxygenase 1
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Mitochondrion Cytosol Membrane	Nucleus
	Molecular Function	RNA Binding RNA Helicase Activity Double-stranded RNA Binding Protein Binding ATP Binding RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding	DNA Binding Iron Ion Binding Zinc Ion Binding Methyl-CpG Binding Methylcytosine Dioxygenase Activity
	Biological Process	Osteoblast Differentiation Positive Regulation Of Myeloid Dendritic Cell Cytokine Production RRNA Processing Transcription By RNA Polymerase II Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Gene Expression, Epigenetic Defense Response To Virus	Inner Cell Mass Cell Differentiation 5-methylcytosine Catabolic Process Chromatin Organization Protein O-linked Glycosylation Positive Regulation Of Cell Proliferation Stem Cell Population Maintenance Positive Regulation Of Histone Methylation Positive Regulation Of Transcription By RNA Polymerase II Oxidative Demethylation DNA Demethylation Negative Regulation Of Methylation-dependent Chromatin Silencing
Pathways		B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol	TET1,2,3 and TDG demethylate DNA
Drugs
Diseases
GWAS		Depression (quantitative trait) ( 20800221)	Chronotype ( 30696823) Height ( 31562340) Pulse pressure ( 30224653) Triglycerides ( 30275531)
Interacting Genes		18 interacting genes: ADAMTS14 CALM1 CSNK2A1 ERG H2AX IL7R JUN KPNA3 MTHFR PIAS1 PNMA2 SGPL1 SRPK2 SUMO2 TERF1 TERF2 TET1 UBE2I	2 interacting genes: DDX21 MBD3
Entrez ID		9188	80312
HPRD ID		05895	09694
Ensembl ID		ENSG00000165732	ENSG00000138336
Uniprot IDs		Q9NR30	Q8NFU7
PDB IDs		2M3D	6ASD
Enriched GO Terms of Interacting Partners?
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