BUB3 and PSTPIP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		BUB3	PSTPIP1
Description		BUB3 mitotic checkpoint protein	proline-serine-threonine phosphatase interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Cytosol Mitotic Checkpoint Complex Bub1-bub3 Complex	Uropod Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Ubiquitin Binding	Protein Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Attachment Of Spindle Microtubules To Kinetochore Anaphase-promoting Complex-dependent Catabolic Process Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Innate Immune Response
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases			Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome
GWAS		Body mass index ( 28892062) Menopause (age at onset) ( 24045676) Right lateral prefrontal cortical growth ( 29682794)	Neurofibrillary tangles ( 31497858)
Interacting Genes		16 interacting genes: BUB1 BUB1B CPNE1 EXOC3 HDAC1 HDAC2 PARP1 PARP2 PSTPIP1 RPL37A SUGT1 THRA TOP1 UBA1 UBR5 WBP4	42 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 DNM2 EXOC5 FAM90A1 FASLG FBXL18 HMG20A KHDRBS1 LSM4 MEFV MFGE8 MVP NAV2 PCDHB14 PRPF31 PTPN12 PTPN18 RINT1 RTP5 RXRB SDCBP SH2D4A SHBG SPG7 SYCE1 TFIP11 TRAF3IP3 TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZNF175 ZNF688
Entrez ID		9184	9051
HPRD ID		04761	05891
Ensembl ID		ENSG00000154473	ENSG00000140368
Uniprot IDs		A0A140VJF3 O43684	A0A0S2Z5P3 O43586
PDB IDs			2DIL
Enriched GO Terms of Interacting Partners?
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