PSTPIP1 and SH2D4A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PSTPIP1	SH2D4A
Description		proline-serine-threonine phosphatase interacting protein 1	SH2 domain containing 4A
Image			No pdb structure
GO Annotations	Cellular Component	Uropod Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Identical Protein Binding	Protein Binding Phosphatase Binding Signaling Adaptor Activity
	Biological Process	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Innate Immune Response	Positive Regulation Of Signal Transduction Negative Regulation Of Phosphatase Activity
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases		Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome
GWAS		Neurofibrillary tangles ( 31497858)	Smooth-surface caries ( 24556642) Urate levels in overweight individuals ( 25811787) Urinary albumin excretion rate in type 1 diabetes ( 24595857)
Interacting Genes		42 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 DNM2 EXOC5 FAM90A1 FASLG FBXL18 HMG20A KHDRBS1 LSM4 MEFV MFGE8 MVP NAV2 PCDHB14 PRPF31 PTPN12 PTPN18 RINT1 RTP5 RXRB SDCBP SH2D4A SHBG SPG7 SYCE1 TFIP11 TRAF3IP3 TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZNF175 ZNF688	44 interacting genes: ALAS1 CASK CCDC172 CDR2 CEP70 CEP76 DBNL FSD2 GOLGA2 GRB2 HCLS1 HMBOX1 IKZF1 KRT40 LDOC1 LZTS2 MAGEA11 MAGEA6 MTUS2 NECAB2 NINL NUTM1 OLIG1 PDE4DIP PNMA1 PPP1CB PSTPIP1 RINT1 SH3GL1 SKAP1 SORBS2 SORBS3 SPAG5 STAM2 STX11 TACC1 TFIP11 TRAF2 TRIM23 TRIM27 UBXN11 USHBP1 VPS52 ZBTB16
Entrez ID		9051	63898
HPRD ID		05891	08340
Ensembl ID		ENSG00000140368	ENSG00000104611
Uniprot IDs		A0A0S2Z5P3 O43586	Q9H788
PDB IDs		2DIL
Enriched GO Terms of Interacting Partners?
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