IL1RL1 and IL33

Number of citations of the paper that reports this interaction (PubMedID 16286016)
971

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo)

		IL1RL1	IL33
Description		interleukin 1 receptor like 1	interleukin 33
Image
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Nucleus Nucleoplasm Nuclear Heterochromatin Cytoplasm Transport Vesicle
	Molecular Function	Interleukin-33 Binding Interleukin-33 Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Interleukin-33 Receptor Binding Cytokine Activity Protein Binding
	Biological Process	Negative Regulation Of T-helper 1 Type Immune Response Immune Response Signal Transduction Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-5 Production Interleukin-33-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Inflammatory Response Positive Regulation Of Chemokine Secretion	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Microglial Cell Activation Involved In Immune Response Negative Regulation Of Leukocyte Migration Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Type 2 Immune Response Protein Deubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Interleukin-33-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Positive Regulation Of Immunoglobulin Secretion Negative Regulation Of Immunoglobulin Secretion Defense Response To Virus Microglial Cell Proliferation Positive Regulation Of Chemokine Secretion Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Neuroinflammatory Response
Pathways		PIP3 activates AKT signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-33 signaling	PIP3 activates AKT signaling Ub-specific processing proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-33 signaling
Drugs
Diseases
GWAS		Adult asthma ( 30578877) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 23028483 21804549 31361310 30929738 27182965 31619474 26620591 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738 29273806) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879) Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 20190752 18311140) Crohn's disease ( 28067908 21102463) Delirium ( 29631748) Eosinophil counts ( 29403010 19198610) FEV1 ( 30804560) Inflammatory bowel disease ( 28067908 23128233) Lung function (FEV1/FVC) ( 30804560) Nasal polyps ( 30643255) Primary biliary cholangitis ( 26394269) Self-reported allergy ( 23817569) Serum protein levels (sST2) ( 23999434) Waist circumference ( 23966867)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Allergy ( 27182965) Asthma ( 21804549 31361310 30929738 20860503 27182965 31619474 29785011 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738 24241537 29273806) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Chronic rhinosinusitis ( 30643255) Eczema ( 31361310) Endometriosis ( 23472165) Medication use (adrenergics, inhalants) ( 31015401) Medication use (antihistamines for systemic use) ( 31015401) Medication use (glucocorticoids) ( 31015401) Nasal polyps ( 30643255) Periodontal microbiota ( 22699663) Self-reported allergy ( 23817569) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Small cell lung carcinoma ( 28604730)
Interacting Genes		8 interacting genes: APP CLEC7A HRAS HYOU1 IL33 MYD88 TIRAP TMED1	5 interacting genes: CASP1 CRMP1 H2AC18 H2BC21 IL1RL1
Entrez ID		9173	90865
HPRD ID		03123	12275
Ensembl ID		ENSG00000115602	ENSG00000137033
Uniprot IDs		Q01638	O95760
PDB IDs		4KC3	2KLL 4KC3
Enriched GO Terms of Interacting Partners?
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