IL1RL1 and TMED1

Number of citations of the paper that reports this interaction (PubMedID 8621446)
12

Data Source:
HPRD (in vivo)

		IL1RL1	TMED1
Description		interleukin 1 receptor like 1	transmembrane p24 trafficking protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Integral Component Of Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Interleukin-33 Binding Interleukin-33 Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Signaling Receptor Binding Protein Binding
	Biological Process	Negative Regulation Of T-helper 1 Type Immune Response Immune Response Signal Transduction Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-5 Production Interleukin-33-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Inflammatory Response Positive Regulation Of Chemokine Secretion	Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Golgi Organization Signal Transduction Cell-cell Signaling
Pathways		PIP3 activates AKT signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-33 signaling
Drugs
Diseases
GWAS		Adult asthma ( 30578877) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 23028483 21804549 31361310 30929738 27182965 31619474 26620591 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738 29273806) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879) Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 20190752 18311140) Crohn's disease ( 28067908 21102463) Delirium ( 29631748) Eosinophil counts ( 29403010 19198610) FEV1 ( 30804560) Inflammatory bowel disease ( 28067908 23128233) Lung function (FEV1/FVC) ( 30804560) Nasal polyps ( 30643255) Primary biliary cholangitis ( 26394269) Self-reported allergy ( 23817569) Serum protein levels (sST2) ( 23999434) Waist circumference ( 23966867)
Interacting Genes		8 interacting genes: APP CLEC7A HRAS HYOU1 IL33 MYD88 TIRAP TMED1	3 interacting genes: IL1RL1 SEC23B SMAD3
Entrez ID		9173	11018
HPRD ID		03123	05653
Ensembl ID		ENSG00000115602	ENSG00000099203
Uniprot IDs		Q01638	Q13445
PDB IDs		4KC3
Enriched GO Terms of Interacting Partners?
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