USP6 and EXOSC8

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		USP6	EXOSC8
Description		ubiquitin specific peptidase 6	exosome component 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Plasma Membrane Recycling Endosome	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleic Acid Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity GTPase Activator Activity Protein Binding Calmodulin Binding Rab GTPase Binding	Exoribonuclease Activity Protein Binding AU-rich Element Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding
	Biological Process	Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Transport Protein Deubiquitination Regulation Of Vesicle-mediated Transport Activation Of GTPase Activity	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Biological_process RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent MRNA Catabolic Process
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575)
Interacting Genes		14 interacting genes: ANKRD44 APP ATXN7L3 CALM2 CDC42 EXOSC8 JAK1 JUN MDFI MYL2 RAB33B RAC1 TFIP11 UBC	49 interacting genes: AEN ATF2 CAB39L COL23A1 COX5A CRMP1 CWC22 DIS3 DUSP23 EEF1DP3 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM90A1 FHOD1 FOXN3 FRG1 LSM1 LSM7 MAPK8IP1 MKRN1 MORN4 MPHOSPH6 MPP6 MTREX N4BP2L2 OTUD4 PDCD1LG2 RASSF1 REL RERG RPP14 RXRB SNRPB SNRPC TCEA2 TFAP4 TXNDC17 TXNDC9 UBC UPF2 USP6 XRN1 XRN2 ZFP36
Entrez ID		9098	11340
HPRD ID		06827	09351
Ensembl ID		ENSG00000129204	ENSG00000120699
Uniprot IDs		P35125	Q96B26
PDB IDs			2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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