USP14 and CCNB1

Number of citations of the paper that reports this interaction (PubMedID 27074503)
50

Data Source:
BioGRID (enzymatic study)

		USP14	CCNB1
Description		ubiquitin specific peptidase 14	cyclin B1
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytosol Plasma Membrane Cell Surface Cytoplasmic Vesicle Synapse Extracellular Exosome	Cyclin-dependent Protein Kinase Holoenzyme Complex Spindle Pole Condensed Nuclear Chromosome Outer Kinetochore Cell Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Centrosome Cytosol Membrane Cyclin B1-CDK1 Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Proteasome Binding	Protein Kinase Activity Patched Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Histone Kinase Activity Ubiquitin-like Protein Ligase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Chemical Synaptic Transmission Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Innate Immune Response Regulation Of Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Oocyte Maturation In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Transcription Initiation From RNA Polymerase II Promoter DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Mitotic Spindle Organization Mitotic Nuclear Envelope Disassembly Mitotic Metaphase Plate Congression Spermatogenesis Response To Mechanical Stimulus Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone Phosphorylation Tissue Regeneration Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Mitotic Cell Cycle Response To DDT Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Cell Division Regulation Of Cell Cycle Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Chromosome Condensation Protein-containing Complex Assembly Cellular Response To Iron(III) Ion Cellular Response To Fatty Acid Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Histone H3-S10 Phosphorylation Involved In Chromosome Condensation
Pathways		Ub-specific processing proteases	E2F-enabled inhibition of pre-replication complex formation Polo-like kinase mediated events Golgi Cisternae Pericentriolar Stack Reorganization APC/C:Cdc20 mediated degradation of Cyclin B Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Depolymerisation of the Nuclear Lamina TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Mitotic Prophase Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional regulation by RUNX2
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS
Interacting Genes		10 interacting genes: CCNB1 COPS5 CXCR4 FANCC SEM1 TRIM11 UBC USP15 USP21 USP28	57 interacting genes: ANAPC11 ARID4A BRCA1 CCNB1IP1 CCNF CDC20 CDC25A CDC25C CDC27 CDC34 CDC6 CDK1 CDKN1A CDKN1B CDT1 EP300 FLNA FZR1 GADD45A GADD45B GADD45G H1-1 H1-5 HERC5 ITPR1 KAT5 MAP4 MEF2C MOK OTUD7B PBK PCNA PIN1 PKMYT1 PLK1 POLA1 PRC1 PRKDC PRKN PTCH1 PTMA RALBP1 RB1 RPA1 RUNX2 SQSTM1 TGFBR2 TP53BP1 TP73 TSC1 TSPYL2 UBE2D2 UBE2N UBE3C UBE3D USP14 XIAP
Entrez ID		9097	891
HPRD ID		06279	00454
Ensembl ID		ENSG00000101557	ENSG00000134057
Uniprot IDs		P54578	P14635
PDB IDs		2AYN 2AYO 5GJQ 6IIK 6IIL 6IIM 6IIN	2B9R 2JGZ 4Y72 4YC3 5HQ0 5LQF 6GU2 6GU3 6GU4
Enriched GO Terms of Interacting Partners?
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