LDB2 and LHX4

Number of citations of the paper that reports this interaction (PubMedID 18330356)
6

Data Source:
BioGRID (two hybrid)

		LDB2	LHX4
Description		LIM domain binding 2	LIM homeobox 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Plasma Membrane Cell Leading Edge	Nuclear Chromatin Nucleus
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Transcription Coregulator Activity Protein Binding Enzyme Binding LIM Domain Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Hair Follicle Development Multicellular Organism Development Epithelial Structure Maintenance Regulation Of Cell Migration Somatic Stem Cell Population Maintenance Regulation Of Kinase Activity Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Placenta Development Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Number of sexual partners ( 30643258) QT interval ( 23534349) Rhegmatogenous retinal detachment ( 23585552) Systemic juvenile idiopathic arthritis ( 27927641) Waist circumference ( 28552196)
Interacting Genes		12 interacting genes: ISL1 LHX4 LHX9 LMO3 LMO4 RASIP1 RILP RLIM SSBP2 SSBP3 SSBP4 TSNAX	22 interacting genes: ADAMTSL4 AXIN1 CHCHD2 FDX2 GOLGA2 IFT172 IKZF1 KRT38 KRT40 LDB2 LONRF1 NRF1 ORC6 SH2D1A SNRNP25 SSX1 TCAP TCF4 TP53BP2 TXNDC5 UBQLN1 USP2
Entrez ID		9079	89884
HPRD ID		16022	03686
Ensembl ID		ENSG00000169744	ENSG00000121454
Uniprot IDs		B7Z6D0 E9PFI4 G5E9Y7 O43679	A0A0S2Z5S4 Q969G2
PDB IDs			5HOD
Enriched GO Terms of Interacting Partners?
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