SH2D4A and PSTPIP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SH2D4A	PSTPIP1
Description		SH2 domain containing 4A	proline-serine-threonine phosphatase interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Uropod Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Phosphatase Binding Signaling Adaptor Activity	Protein Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Signal Transduction Negative Regulation Of Phosphatase Activity	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Innate Immune Response
Pathways			The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases			Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome
GWAS		Smooth-surface caries ( 24556642) Urate levels in overweight individuals ( 25811787) Urinary albumin excretion rate in type 1 diabetes ( 24595857)	Neurofibrillary tangles ( 31497858)
Interacting Genes		44 interacting genes: ALAS1 CASK CCDC172 CDR2 CEP70 CEP76 DBNL FSD2 GOLGA2 GRB2 HCLS1 HMBOX1 IKZF1 KRT40 LDOC1 LZTS2 MAGEA11 MAGEA6 MTUS2 NECAB2 NINL NUTM1 OLIG1 PDE4DIP PNMA1 PPP1CB PSTPIP1 RINT1 SH3GL1 SKAP1 SORBS2 SORBS3 SPAG5 STAM2 STX11 TACC1 TFIP11 TRAF2 TRIM23 TRIM27 UBXN11 USHBP1 VPS52 ZBTB16	42 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 DNM2 EXOC5 FAM90A1 FASLG FBXL18 HMG20A KHDRBS1 LSM4 MEFV MFGE8 MVP NAV2 PCDHB14 PRPF31 PTPN12 PTPN18 RINT1 RTP5 RXRB SDCBP SH2D4A SHBG SPG7 SYCE1 TFIP11 TRAF3IP3 TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZNF175 ZNF688
Entrez ID		63898	9051
HPRD ID		08340	05891
Ensembl ID		ENSG00000104611	ENSG00000140368
Uniprot IDs		Q9H788	A0A0S2Z5P3 O43586
PDB IDs			2DIL
Enriched GO Terms of Interacting Partners?
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