WASF1 and SRGAP3

Number of citations of the paper that reports this interaction (PubMedID 12447388)
65

Data Source:
HPRD (in vivo, in vitro)

		WASF1	SRGAP3
Description		WASP family member 1	SLIT-ROBO Rho GTPase activating protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Cytoskeleton Focal Adhesion Actin Cytoskeleton Lamellipodium SCAR Complex Dendrite Cytoplasm Protein-containing Complex Postsynapse	Cytoplasm Cytosol
	Molecular Function	Actin Binding Protein Binding Rac GTPase Binding Protein Kinase A Binding	GTPase Activator Activity Protein Binding Rac GTPase Binding
	Biological Process	Receptor-mediated Endocytosis Rac Protein Signal Transduction Actin Filament Polymerization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein-containing Complex Assembly Lamellipodium Morphogenesis Dendrite Extension Modification Of Postsynaptic Actin Cytoskeleton Dendritic Transport Of Mitochondrion Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Signal Transduction Negative Regulation Of Cell Migration Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Rho GTPase cycle Inactivation of CDC42 and RAC1
Drugs
Diseases
GWAS			3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Body fat percentage ( 31752434) Lead levels in blood ( 25820613) Rapid automised naming of letters ( 30741946)
Interacting Genes		31 interacting genes: ABI1 ABL1 ACTB ACTG1 ACTR2 ACTR3 BAD BAIAP2 BRK1 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP FYN GNAI1 GRB2 IFT20 IL12A MAPKAPK2 NCK1 NCKAP1 NYAP2 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRIP10	9 interacting genes: DISC1 DTNBP1 FASLG KDM1A PRMT6 SMARCC2 SUV39H1 TNIK WASF1
Entrez ID		8936	9901
HPRD ID		05434	12108
Ensembl ID		ENSG00000112290	ENSG00000196220
Uniprot IDs		Q92558	O43295
PDB IDs		3P8C 4N78
Enriched GO Terms of Interacting Partners?
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