KYAT1 and VAC14

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		KYAT1	VAC14
Description		kynurenine aminotransferase 1	VAC14 component of PIKFYVE complex
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Golgi Membrane Extrinsic Component Of Vacuolar Membrane Vacuolar Membrane Endoplasmic Reticulum Cytosol Endosome Membrane Early Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle PAS Complex
	Molecular Function	Protein Binding Transaminase Activity Kynurenine-oxoglutarate Transaminase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity Glutamine-phenylpyruvate Transaminase Activity Cysteine-S-conjugate Beta-lyase Activity	Protein Binding Signaling Receptor Activity
	Biological Process	L-phenylalanine Catabolic Process Tryptophan Catabolic Process Cellular Modified Amino Acid Metabolic Process Cellular Amino Acid Biosynthetic Process Kynurenine Metabolic Process L-kynurenine Catabolic Process	Phosphatidylinositol Biosynthetic Process Signal Transduction Viral Process Positive Regulation Of Kinase Activity
Pathways		Tryptophan catabolism Phenylalanine metabolism Glutamate and glutamine metabolism	Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs		Pyridoxal Phosphate Pyridoxamine-5'-Phosphate D-Phenylalanine N'-Pyridoxyl-Lysine-5'-Monophosphate 1H-INDOL-3-YLACETIC ACID
Diseases
GWAS			Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Pulse pressure ( 28135244)
Interacting Genes		3 interacting genes: APP TRIP13 VAC14	53 interacting genes: ACSS1 APP ASB13 BCL2L1 BHLHE40 C11orf54 C4orf33 CASP1 CCDC103 CD209 CDRT4 CNTN2 COL8A1 CRK DDAH2 FNDC3B GALT GINS3 HNRNPLL JMJD7 KRTAP19-5 KRTAP19-7 KYAT1 LINC00518 LPAL2 MGAT5B MPPED2 MTMR9 MVP NGB NOS1 NTAQ1 PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PRADC1 PRR13 PRR20A RBFOX2 RHOXF2 SIGLEC5 SMUG1 SNF8 SPRYD7 SRPK2 TCEANC TP53BP1 ZCWPW1 ZNF34
Entrez ID		883	55697
HPRD ID		02769	07660
Ensembl ID		ENSG00000171097	ENSG00000103043
Uniprot IDs		A8K563 B7Z4W5 Q16773	Q08AM6
PDB IDs		1W7L 1W7M 1W7N 3FVS 3FVU 3FVX 4WLH 4WLJ 4WP0
Enriched GO Terms of Interacting Partners?
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