LIN7A and ZYX

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LIN7A	ZYX
Description		lin-7 homolog A, crumbs cell polarity complex component	zyxin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse Extracellular Exosome MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane	Stress Fiber Nucleus Cytoplasm Cytosol Adherens Junction Focal Adhesion Phagocytic Vesicle
	Molecular Function	Protein Binding L27 Domain Binding	RNA Binding Protein Binding Metal Ion Binding
	Biological Process	Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Synaptic Vesicle Transport Inner Ear Development Protein-containing Complex Assembly Protein Localization To Basolateral Plasma Membrane	Cell-matrix Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Viral Process Stress Fiber Assembly Regulation Of Inflammatory Response Cellular Response To Interferon-gamma
Pathways		Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs			Artenimol
Diseases
GWAS		Age-related cataracts (age at onset) ( 25352737) Dental caries ( 23259602)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 28240269) White blood cell count (basophil) ( 27863252)
Interacting Genes		19 interacting genes: ABCA1 ADGRB1 APP BAIAP2 CASK DLG2 DLG3 DLG4 DNAJC5 FAM9B GOLGA2 GRIN2B KCNJ12 MPP3 MPP5 MPP6 NOTCH2NLA SLC6A12 ZYX	30 interacting genes: ACTN1 ATXN1 BSPRY ENAH HIPK3 IMP3 LASP1 LATS1 LIN7A NEBL NEDD9 NME5 OPRM1 PDLIM5 PHF21A RABEPK RGS2 RPH3AL RTN4IP1 SIAH1 SREBF2 TES TUFT1 VASP VAV1 VAV3 WNK1 YPEL3 ZHX1 ZNF384
Entrez ID		8825	7791
HPRD ID		04542	03592
Ensembl ID		ENSG00000111052	ENSG00000159840
Uniprot IDs		O14910	Q15942 Q96AF9
PDB IDs
Enriched GO Terms of Interacting Partners?
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