MPDZ and CLDN5

Number of citations of the paper that reports this interaction (PubMedID 12403818)
65

Data Source:
HPRD (in vivo)

		MPDZ	CLDN5
Description		multiple PDZ domain crumbs cell polarity complex component	claudin 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Bicellular Tight Junction Postsynaptic Density Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite Cytoplasmic Vesicle Schmidt-Lanterman Incisure	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apicolateral Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Tight Junction
	Molecular Function	Protein Binding Protein C-terminus Binding	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Cell Adhesion Viral Process	Outflow Tract Morphogenesis Cell-cell Junction Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Learning Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Positive Regulation Of Protein Binding Maintenance Of Permeability Of Blood-brain Barrier Negative Regulation Of Vascular Permeability Roof Of Mouth Development Face Morphogenesis Tight Junction Assembly Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Bicellular Tight Junction Assembly Establishment Of Blood-retinal Barrier Regulation Of Bicellular Tight Junction Assembly
Pathways			Tight junction interactions RUNX1 regulates expression of components of tight junctions
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442) Corneal hysteresis ( 30894546) Corneal structure ( 23291589) Heel bone mineral density ( 30598549 28869591) Refractive astigmatism ( 30306274)
Interacting Genes		16 interacting genes: ABCA1 CAMK2A CLDN1 CLDN5 CRHR1 CSPG4 DRD3 F11R HTR2C KIT MTNR1A PLEKHA1 PLEKHA2 RNF5 SYNGAP1 TSC22D2	3 interacting genes: CLDN3 MPDZ TJP1
Entrez ID		8777	7122
HPRD ID		09155	03654
Ensembl ID		ENSG00000107186	ENSG00000184113
Uniprot IDs		O75970	D3DX19 O00501
PDB IDs		2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1
Enriched GO Terms of Interacting Partners?
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