MPDZ and ABCA1

Number of citations of the paper that reports this interaction (PubMedID 16192269)
20

Data Source:
HPRD (in vitro)

		MPDZ	ABCA1
Description		multiple PDZ domain crumbs cell polarity complex component	ATP binding cassette subfamily A member 1
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GO Annotations	Cellular Component	Cytoplasm Bicellular Tight Junction Postsynaptic Density Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite Cytoplasmic Vesicle Schmidt-Lanterman Incisure	Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endocytic Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein C-terminus Binding	Signaling Receptor Binding Lipid Transporter Activity Protein Binding ATP Binding High-density Lipoprotein Particle Binding Cholesterol Binding ATPase Activity Syntaxin Binding Phosphatidylcholine Binding Small GTPase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Apolipoprotein A-I Receptor Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances ATPase Binding Phosphatidylcholine-translocating ATPase Activity Phosphatidylserine-translocating ATPase Activity Intermembrane Cholesterol Transfer Activity
	Biological Process	Cell Adhesion Viral Process	Protein Lipidation Lipid Transport Phagocytosis, Engulfment Lysosome Organization G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Nutrient Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Endosomal Transport Regulation Of Lipid Metabolic Process Intracellular Cholesterol Transport Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux High-density Lipoprotein Particle Assembly Response To Laminar Fluid Shear Stress Apolipoprotein A-I-mediated Signaling Pathway Response To Drug Cholesterol Homeostasis Reverse Cholesterol Transport Phospholipid Translocation Interleukin-1 Beta Secretion Transmembrane Transport Phospholipid Homeostasis Platelet Dense Granule Organization Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Cholesterol Cellular Response To Low-density Lipoprotein Particle Stimulus Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of High-density Lipoprotein Particle Assembly
Pathways			PPARA activates gene expression Defective ABCA1 causes Tangier disease HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs			ATP Glyburide Probucol
Diseases			Tangier disease Hypoalphalipoproteinemia
GWAS		Central corneal thickness ( 29760442) Corneal hysteresis ( 30894546) Corneal structure ( 23291589) Heel bone mineral density ( 30598549 28869591) Refractive astigmatism ( 30306274)	Advanced age-related macular degeneration ( 26691988) Allergic rhinitis ( 25085501) Aluminium levels ( 26025379) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Cardiometabolic and hematological traits ( 27668658) Cholesterol, total ( 24097068 25961943 20686565 26582766) Coronary artery disease ( 29212778) Glaucoma ( 30104761 31959993 30054594) Glaucoma (high intraocular pressure) ( 25173107) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 25173105 29452408) Gout ( 22179738) HDL cholesterol ( 24097068 21909109 28270201 18193043 18193044 20864672 26160806 19060906 23505323 19060911 30275531 21347282 25961943 26780889 20686565 26582766) HDL cholesterol levels ( 31694877 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 30718733 29403010 29615537) Intraocular pressure ( 29617998 25173106 31798171 29785010 31959993 30054594 28073927 30591961 29235454) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol ( 30275531) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 22286219) Low high density lipoprotein cholesterol levels ( 26879886) Lung cancer in ever smokers ( 28604730) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 30382898 31589552) Metabolite levels ( 31628463 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Myopia (pathological) ( 23049088) Pelvic organ prolapse ( 26545240) Periodontitis (Mean PAL) ( 24024966) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Response to fenofibrate (total cholesterol levels) ( 27002377) Total cholesterol levels ( 28334899 29403010 30275531) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531) Urate levels ( 31578528) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		16 interacting genes: ABCA1 CAMK2A CLDN1 CLDN5 CRHR1 CSPG4 DRD3 F11R HTR2C KIT MTNR1A PLEKHA1 PLEKHA2 RNF5 SYNGAP1 TSC22D2	42 interacting genes: AOX1 APOA1 ARHGEF11 ARHGEF12 ATXN10 CSNK2A1 CSNK2A2 DLG2 DLG3 DLG5 ERBIN ERP44 FADD GOPC IKBKG LIMK1 LIN7A LIN7B LIN7C LMO7 LNX1 MPDZ MPP6 PDLIM3 PDLIM4 PDZK1 PLTP PRKACA PRPF8 RAPGEF6 RIMS2 SDHB SHANK1 SLC25A34 SNTA1 SNTB1 SNTB2 SPTLC1 TGM2 TIAM1 TRIM27 UGP2
Entrez ID		8777	19
HPRD ID		09155	02501
Ensembl ID		ENSG00000107186	ENSG00000165029
Uniprot IDs		O75970	B2RUU2 B7XCW9 O95477
PDB IDs		2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1	5XJY
Enriched GO Terms of Interacting Partners?
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