HYAL2 and WWOX

Number of citations of the paper that reports this interaction (PubMedID 27845895)
11

Data Source:
BioGRID (two hybrid)

		HYAL2	WWOX
Description		hyaluronidase 2	WW domain containing oxidoreductase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosome Endoplasmic Reticulum Cytosol Plasma Membrane Microvillus Cell Surface Apical Plasma Membrane Endocytic Vesicle Anchored Component Of External Side Of Plasma Membrane Cytoplasmic Vesicle Membrane Raft Anchored Component Of Plasma Membrane Perinuclear Region Of Cytoplasm RNA Polymerase II Transcription Factor Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Microvillus RNA Polymerase II Transcription Factor Complex
	Molecular Function	Virus Receptor Activity Transcription Coactivator Activity Hyalurononglucosaminidase Activity Protein Binding Hyaluronic Acid Binding Enzyme Binding Receptor Signaling Protein Tyrosine Kinase Inhibitor Activity Receptor Tyrosine Kinase Binding Hyaluronoglucuronidase Activity Transforming Growth Factor Beta Binding	Transcription Coactivator Activity Protein Binding Oxidoreductase Activity Enzyme Binding
	Biological Process	Response To Reactive Oxygen Species Kidney Development Hematopoietic Progenitor Cell Differentiation Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Response To Virus Multicellular Organism Aging Negative Regulation Of Fibroblast Migration Fusion Of Virus Membrane With Host Plasma Membrane Transformation Of Host Cell By Virus Hyaluronan Catabolic Process Negative Regulation Of Cell Growth Positive Regulation Of Urine Volume Monocyte Activation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of MAP Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Transcription By RNA Polymerase II Response To Antibiotic Viral Entry Into Host Cell Skeletal System Morphogenesis Positive Regulation Of Inflammatory Response Cartilage Development Defense Response To Virus Negative Regulation Of Protein Kinase B Signaling Multicellular Organismal Iron Ion Homeostasis Negative Regulation Of Protein Tyrosine Kinase Activity Renal Water Absorption Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To UV-B Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Skeletal System Morphogenesis Oxidation-reduction Process Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Hyaluronan uptake and degradation	Nuclear signaling by ERBB4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
Drugs
Diseases
GWAS		Body mass index ( 26426971) Sleep duration (short sleep) ( 30846698)	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Alzheimer's disease (late onset) ( 30820047) Anorexia nervosa ( 23568457) Bipolar disorder (body mass index interaction) ( 24322204) Brain volume in infants (white matter) ( 28763065) Cardiac structure and function ( 19584346) Clozapine-induced cytotoxicity ( 25656473) Colorectal cancer ( 30529582 29228715) Daytime sleep phenotypes ( 27126917) Diffusing capacity of carbon monoxide ( 30694715) Early-onset Parkinson's disease ( 28256260) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Familial squamous cell lung carcinoma ( 29924316) FEV1 ( 30804560) Hip shape (DXA scan) ( 30320955) Idiopathic dilated cardiomyopathy ( 29495422) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Metabolite levels ( 23823483) Metabolite levels (5-HIAA) ( 23319000) Molybdenum levels ( 26025379) Multiple sclerosis ( 31604244 24076602) Obesity ( 21552555) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Radiation response ( 20923822) Response to amphetamines ( 22952603) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Serum thyroid-stimulating hormone levels ( 25436638) Serum uric acid levels in response to allopurinol in gout ( 25676789) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Systemic juvenile idiopathic arthritis ( 27927641) Type 2 diabetes ( 22158537) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		8 interacting genes: FHL3 KRTAP10-3 KRTAP3-2 MST1R SMAD2 SMAD3 SMAD4 WWOX	25 interacting genes: APBB2 CLNK CPSF2 CPSF7 ERBB4 EZR FIP1L1 HNRNPK HYAL2 LATS1 MAPK8 NUDT21 SCAMP3 SEC23IP SF3B3 SMAD4 SRC TCERG1 TFAP2C TNK2 TP53 TP73 UBB WDR33 WIPF2
Entrez ID		8692	51741
HPRD ID		04649	05501
Ensembl ID		ENSG00000068001	ENSG00000186153
Uniprot IDs		Q12891	A0A411HBC7 Q9NZC7
PDB IDs			1WMV
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?