PRPF38A and POLA2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRPF38A	POLA2
Description		pre-mRNA processing factor 38A	DNA polymerase alpha 2, accessory subunit
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Membrane U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	RNA Binding Protein Binding	Molecular_function DNA Binding DNA-directed DNA Polymerase Activity
	Biological Process	MRNA Splicing, Via Spliceosome	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process
Pathways		mRNA Splicing - Major Pathway	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs			Dacarbazine
Diseases
GWAS			Acne (severe) ( 24927181)
Interacting Genes		21 interacting genes: APP CHERP CLK1 CLK2 CSNK2A1 DHX8 GTF3C1 JMJD6 MAPK6 POLA2 PPIG PRMT5 RBM39 RNPS1 SDCBP SDCBP2 SRPK1 SRPK2 SRSF4 U2AF1 ZCCHC10	41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2
Entrez ID		84950	23649
HPRD ID		10972	10160
Ensembl ID		ENSG00000134748	ENSG00000014138
Uniprot IDs		Q8NAV1	Q14181
PDB IDs		4RZ9 4RZA 5F5S 5O9Z 6AHD	2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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