POLA2 and HELB

Number of citations of the paper that reports this interaction (PubMedID 12181327)
15

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		POLA2	HELB
Description		DNA polymerase alpha 2, accessory subunit	DNA helicase B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol	Intracellular Nucleus DNA Replication Factor A Complex Cytoplasm Site Of Double-strand Break
	Molecular Function	Molecular_function DNA Binding DNA-directed DNA Polymerase Activity	RNA Binding ATP Binding Single-stranded DNA-dependent ATP-dependent DNA Helicase Activity 5'-3' DNA Helicase Activity Protein-containing Complex Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Repair Cellular Response To DNA Damage Stimulus DNA Duplex Unwinding Regulation Of DNA Double-strand Break Processing Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs		Dacarbazine
Diseases
GWAS		Acne (severe) ( 24927181)	Menopause (age at onset) ( 26414677) White blood cell count (basophil) ( 29403010 27863252)
Interacting Genes		41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2	3 interacting genes: POLA1 POLA2 RPA1
Entrez ID		23649	92797
HPRD ID		10160	09979
Ensembl ID		ENSG00000014138	ENSG00000127311
Uniprot IDs		Q14181	Q8NG08
PDB IDs		2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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