CAT and EHHADH

Number of citations of the paper that reports this interaction (PubMedID 29568061)
14

Data Source:
BioGRID (proximity labelling technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology)

		CAT	EHHADH
Description		catalase	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Lysosome Peroxisome Peroxisomal Membrane Peroxisomal Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Membrane Protein-containing Complex Secretory Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Ficolin-1-rich Granule Lumen	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Peroxisome Targeting Sequence Binding Aminoacylase Activity Catalase Activity Antioxidant Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding NADP Binding	3-hydroxyacyl-CoA Dehydrogenase Activity Dodecenoyl-CoA Delta-isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Long-chain-enoyl-CoA Hydratase Activity Enzyme Binding
	Biological Process	Response To Reactive Oxygen Species Osteoblast Differentiation Ureteric Bud Development Response To Hypoxia Protein Targeting To Peroxisome Triglyceride Metabolic Process Aging Cholesterol Metabolic Process Aerobic Respiration Response To Light Intensity UV Protection Response To Ozone Response To Lead Ion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Response To Inactivity Hemoglobin Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Estradiol Response To Insulin Response To Vitamin A Response To Vitamin E Response To L-ascorbic Acid Cellular Response To Oxidative Stress Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Response To Ethanol Response To Cadmium Ion Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cell Division Response To Hyperoxia Response To Fatty Acid Cellular Response To Growth Factor Stimulus Response To Phenylpropanoid Cellular Oxidant Detoxification	Internal Protein Amino Acid Acetylation Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase
Pathways		Detoxification of Reactive Oxygen Species Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs		Fomepizole	NADH
Diseases		Acatalasia, including: Acatalasemia; Takahara's disease; Hypocatalasemia
GWAS		Blood protein levels ( 30072576 29875488 28240269)	Cognitive performance ( 19734545) Major depressive disorder ( 27519822 21042317)
Interacting Genes		8 interacting genes: ABL1 ABL2 APP EHHADH KEAP1 PTPN11 SUMO4 TLR10	27 interacting genes: ACTB ACTG1 BHLHE40 CAT CBS CCDC102B DES FUNDC1 KCTD6 KCTD9 KRTAP10-7 LZTS2 MID1 NECAB2 PNMA1 SCP2 SSNA1 SSX2IP TNIP1 TPP2 TRAF1 TRIM27 TRIM41 TRIM54 TRIM55 TRIM63 ZBTB9
Entrez ID		847	1962
HPRD ID		00282	06125
Ensembl ID		ENSG00000121691	ENSG00000113790
Uniprot IDs		A0A384P5Q0 P04040	Q08426
PDB IDs		1DGB 1DGF 1DGG 1DGH 1F4J 1QQW
Enriched GO Terms of Interacting Partners?
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