KLF11 and APH1A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		KLF11	APH1A
Description		Kruppel like factor 11	aph-1 homolog A, gamma-secretase subunit
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Focal Adhesion Nuclear Body	Mitochondrion Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Integral Component Of Membrane Golgi Cisterna Membrane Gamma-secretase Complex Integral Component Of Presynaptic Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	Endopeptidase Activity Protein Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Cellular Response To Peptide	Metanephros Development Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway
Pathways			Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs			E-2012
Diseases		Maturity onset diabetes of the young (MODY)
GWAS		Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Feeling worry ( 29500382) Heel bone mineral density ( 30598549) Height ( 28552196) Neurociticism ( 29500382) Prostate cancer ( 23535732)	Bipolar disorder ( 31043756) Chronotype ( 26955885) Morning vs. evening chronotype ( 26955885 26835600) Schizophrenia ( 25056061)
Interacting Genes		12 interacting genes: APH1A APPBP2 ATXN1 CBX1 CBX3 CLU HDAC1 MAPK1 SIN3A TIMM13 TXNDC9 YWHAZ	17 interacting genes: ATF4 BHLHE40 CEP350 CREB3 GLP1R GPATCH8 HES1 HIVEP1 KLF11 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 THPO TLE1 TMED10
Entrez ID		8462	51107
HPRD ID		04488	06360
Ensembl ID		ENSG00000172059	ENSG00000117362
Uniprot IDs		B7ZAX4 O14901 Q53QU8	B4DUG7 Q96BI3
PDB IDs		1PO4	5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC
Enriched GO Terms of Interacting Partners?
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