APH1A and CEP350

		APH1A	CEP350
Description		aph-1 homolog A, gamma-secretase subunit	centrosomal protein 350
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GO Annotations	Cellular Component	Mitochondrion Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Integral Component Of Membrane Golgi Cisterna Membrane Gamma-secretase Complex Integral Component Of Presynaptic Membrane	Nucleus Cytoplasm Centrosome Centriole Spindle Membrane Cell Projection
	Molecular Function	Endopeptidase Activity Protein Binding	Protein Binding Microtubule Binding
	Biological Process	Metanephros Development Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway	Microtubule Anchoring
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs		E-2012
Diseases
GWAS		Bipolar disorder ( 31043756) Chronotype ( 26955885) Morning vs. evening chronotype ( 26955885 26835600) Schizophrenia ( 25056061)	Anorexia nervosa ( 23568457) Smoking initiation ( 30617275)
Interacting Genes		17 interacting genes: ATF4 BHLHE40 CEP350 CREB3 GLP1R GPATCH8 HES1 HIVEP1 KLF11 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 THPO TLE1 TMED10	11 interacting genes: ADIPOR1 APH1A APTX CEP19 ID3 NR1H3 PLEKHA5 PPARA PPARD PPARG RSRP1
Entrez ID		51107	9857
HPRD ID		06360	09870
Ensembl ID		ENSG00000117362	ENSG00000135837
Uniprot IDs		B4DUG7 Q96BI3	Q5VT06
PDB IDs		5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC	2COZ
Enriched GO Terms of Interacting Partners?
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