DYRK2 and UBR5

  • Number of citations of the paper that reports this interaction (PubMedID 19287380)
  • 70
  • Data Source:
  • BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

DYRK2

UBR5

Description dual specificity tyrosine phosphorylation regulated kinase 2 ubiquitin protein ligase E3 component n-recognin 5
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GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728)
  • Daytime sleep phenotypes ( 27126917)
  • Itch intensity from mosquito bite ( 28199695)
  • Itch intensity from mosquito bite adjusted by bite size ( 28199695)
  • Metabolite levels ( 23823483)
  • Mosquito bite size ( 28199695)
  • Systemic lupus erythematosus ( 28714469)
  • Chromosomal aberration frequency (total) ( 31586183)
  • Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209)
  • Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes 22 interacting genes: APP ATM DYRK4 EIF2B5 H2BC21 H3-4 IKZF1 KATNA1 KXD1 LRRK2 LZTS2 MAPT MDM2 NR1I2 RAD54B SIAH2 SP100 TERT UBE2D1 UBR5 WDR62 ZBTB9 31 interacting genes: BARD1 BUB3 CIB1 CSPP1 DYRK2 ERG GSK3B KPNA1 KPNA2 KPNB1 MAPK1 MOAP1 NR1I2 OTUD5 PAIP1 PAIP2 PCK1 PGR SATB1 SMAD2 SOX2 TCEA1 TOPBP1 TXNIP UBC UBE2A UBE2B UBE2D2 UBE2D3 UBE2L3 ZNF207
Entrez ID 8445 51366
HPRD ID 04606 06436
Ensembl ID ENSG00000127334 ENSG00000104517
Uniprot IDs Q92630 O95071
PDB IDs 3K2L 3KVW 4AZF 5LXC 5LXD 5ZTN 6HDP 6HDR 6K0J 1I2T 2QHO 3PT3
Enriched GO Terms of Interacting Partners?
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