UBR5 and PCK1

Number of citations of the paper that reports this interaction (PubMedID 30552140)
0

Data Source:
BioGRID (pull down)

		UBR5	PCK1
Description		ubiquitin protein ligase E3 component n-recognin 5	phosphoenolpyruvate carboxykinase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm	Cell Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding Ubiquitin Protein Ligase Activity	Magnesium Ion Binding Phosphoenolpyruvate Carboxykinase (GTP) Activity GTP Binding GDP Binding Manganese Ion Binding Carboxylic Acid Binding
	Biological Process	Protein Polyubiquitination DNA Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Gene Expression Viral Process Positive Regulation Of Protein Import Into Nucleus Progesterone Receptor Signaling Pathway Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Histone H2A K63-linked Ubiquitination Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair	Glucose Metabolic Process Pyruvate Metabolic Process Gluconeogenesis Oxaloacetate Metabolic Process Internal Protein Amino Acid Acetylation Aging Response To Activity Propionate Catabolic Process Response To Lipopolysaccharide Response To Insulin Cellular Response To Insulin Stimulus Response To Lipid Glucose Homeostasis Response To Starvation Glycerol Biosynthetic Process From Pyruvate Cellular Response To Potassium Ion Starvation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Acidic PH Hepatocyte Differentiation Response To Interleukin-6 Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Glucagon Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Response To Methionine
Pathways			Abacavir metabolism Transcriptional regulation of white adipocyte differentiation Gluconeogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs			Phosphoenolpyruvate 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine Phosphomethylphosphonic Acid-Guanylate Ester
Diseases
GWAS		Chromosomal aberration frequency (total) ( 31586183) Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209) Type 2 diabetes (age of onset) ( 28060188)	Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 31451708) Prudent dietary pattern ( 28644415) Response to fenofibrate (adiponectin levels) ( 23149075) Serum alkaline phosphatase levels ( 31666285) Triglycerides ( 30275531) Type 2 diabetes ( 23300278)
Interacting Genes		31 interacting genes: BARD1 BUB3 CIB1 CSPP1 DYRK2 ERG GSK3B KPNA1 KPNA2 KPNB1 MAPK1 MOAP1 NR1I2 OTUD5 PAIP1 PAIP2 PCK1 PGR SATB1 SMAD2 SOX2 TCEA1 TOPBP1 TXNIP UBC UBE2A UBE2B UBE2D2 UBE2D3 UBE2L3 ZNF207	6 interacting genes: APP C1R FBXO25 IKBKG RAE1 UBR5
Entrez ID		51366	5105
HPRD ID		06436	02028
Ensembl ID		ENSG00000104517	ENSG00000124253
Uniprot IDs		O95071	P35558
PDB IDs		1I2T 2QHO 3PT3	1KHB 1KHE 1KHF 1KHG 1M51 1NHX 2GMV
Enriched GO Terms of Interacting Partners?
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