SHARPIN and TRAF1

Number of citations of the paper that reports this interaction (PubMedID 27893701)
14

Data Source:
BioGRID (pull down)

		SHARPIN	TRAF1
Description		SHANK associated RH domain interactor	TNF receptor associated factor 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol Postsynaptic Density Cell Junction Dendrite LUBAC Complex	Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Plasma Membrane Receptor Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding
	Biological Process	Mitochondrion Organization I-kappaB Kinase/NF-kappaB Signaling Brain Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Nuclear Changes Keratinization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway	Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Protein-containing Complex Assembly Protein K63-linked Ubiquitination Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Neurexins and neuroligins	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway
Drugs
Diseases
GWAS		Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Celiac disease or Rheumatoid arthritis ( 21383967) Lymphocyte counts ( 27863252) Pulse pressure ( 30578418) Rheumatoid arthritis ( 30891314 24782177 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		16 interacting genes: ACTR2 ACTR3 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 PPIL3 SHANK1 SHANK2 TRAF1 TXN2 UBC YOD1	186 interacting genes: A1CF ABHD17A ACTN3 AKAP17A AQP1 ARNT2 ARSJ BARD1 BCAS2 BCL6 BEX2 BEX3 BIRC2 BIRC3 C1orf109 C1orf216 C2CD6 CARHSP1 CASP10 CASP3 CASP6 CASP8 CCDC116 CCDC120 CCDC146 CCDC198 CCHCR1 CD40 CDCA3 CDKN1A CDKN2B CFLAR CHCHD3 CNTRL COX5B CRYGA CYB5R2 DEPTOR DGCR6 DMRT3 DOK3 EDAR EHHADH EWSR1 FAM161A FAM86C1P FBF1 FBXL18 FOSL2 GATA1 GATA2 GATAD2B GEM GFI1B GIT2 GLRX3 GMCL2 GNG5 GOLGA2 GORASP2 GRAP2 HAUS1 HEY2 HIVEP3 HMG20B HOXA1 HOXD12 IKBKB JOSD1 KIAA1217 KIF1A KLHL38 KPNA2 LATS1 LCOR LNX1 LNX2 LTBR MACIR MAP3K14 MAP6 MAPRE2 METTL17 MORN3 MOS MYEF2 NEBL NOL4L-DT NTAQ1 NUFIP2 NUP58 OLIG3 PBX3 PDE4D PHF21A PIN1 PKN1 PLAC8 PLEKHN1 POM121L4P POP5 PPP1R13B PRDM7 PRKAB2 PSMA1 PSMB1 QRICH1 RASAL2 RASSF5 RBCK1 RBM41 RBM45 RIPK1 RIPK2 RNF31 RTP5 SCNM1 SDCBP2 SH3GLB2 SHARPIN SHFL SIK3 SLC25A48 SLC25A6 SNW1 SPG21 SPOP SRC SSC5D STK3 SUMO2 SYCE1 TANK TBC1D16 TCL1A TEAD4 TFAP4 TFPT THAP7 TICAM1 TIFA TLE5 TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TNFSF9 TRADD TRAF2 TRAF3IP2 TRAF6 TRAIP TRIM23 TRIM37 TRIM42 TRPV6 TSSC4 USP7 WAC ZBTB1 ZBTB16 ZC2HC1C ZFYVE21 ZFYVE26 ZNF124 ZNF20 ZNF250 ZNF417 ZNF440 ZNF502 ZNF512B ZNF564 ZNF572 ZNF581 ZNF587 ZNF662 ZNF688 ZNF697
Entrez ID		81858	7185
HPRD ID		15463	03418
Ensembl ID		ENSG00000179526	ENSG00000056558
Uniprot IDs		Q6PJD5 Q9H0F6	Q13077
PDB IDs		4EMO 5X0W	3M0D 5E1T 5H10
Enriched GO Terms of Interacting Partners?
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