SHARPIN and ITGAL

Number of citations of the paper that reports this interaction (PubMedID 26600301)
9

Data Source:
BioGRID (pull down, unspecified method, far western blotting, affinity chromatography technology)

		SHARPIN	ITGAL
Description		SHANK associated RH domain interactor	integrin subunit alpha L
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol Postsynaptic Density Cell Junction Dendrite LUBAC Complex	Plasma Membrane Integrin Complex Cell Surface Membrane Integrin AlphaL-beta2 Complex Specific Granule Membrane Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding	Protein Binding ICAM-3 Receptor Activity Protein-containing Complex Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Mitochondrion Organization I-kappaB Kinase/NF-kappaB Signaling Brain Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Nuclear Changes Keratinization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Phagocytosis Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Extracellular Matrix Organization Memory T Cell Extravasation Receptor Clustering Neutrophil Degranulation Regulation Of Immune Response Leukocyte Migration Cell-cell Adhesion
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Neurexins and neuroligins	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Neutrophil degranulation RUNX3 Regulates Immune Response and Cell Migration
Drugs			Efalizumab Antithymocyte immunoglobulin (rabbit) Lovastatin Simvastatin 1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine LFA703 (S)-2-((S)-3-ISOBUTYL-2,5-DIOXO-4-QUINOLIN-3-YLMETHYL-[1,4]DIAZEPAN-1YL)-N-METHYL-3-NAPHTALEN-2-YL-PROPIONAMIDE 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline Lifitegrast
Diseases
GWAS		Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil percentage of white cells ( 27863252) Smooth-surface caries ( 24556642) Ulcerative colitis ( 28067908 23128233) White blood cell count ( 27863252)
Interacting Genes		16 interacting genes: ACTR2 ACTR3 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 PPIL3 SHANK1 SHANK2 TRAF1 TXN2 UBC YOD1	7 interacting genes: F11R ICAM1 ICAM3 ICAM5 PTPRC RANBP9 SHARPIN
Entrez ID		81858	3683
HPRD ID		15463	01079
Ensembl ID		ENSG00000179526	ENSG00000005844
Uniprot IDs		Q6PJD5 Q9H0F6	B2RAL6 P20701
PDB IDs		4EMO 5X0W	1CQP 1DGQ 1IJ4 1LFA 1MJN 1MQ8 1MQ9 1MQA 1RD4 1T0P 1XDD 1XDG 1XUO 1ZON 1ZOO 1ZOP 2ICA 2K8O 2M3E 2O7N 3BN3 3BQM 3BQN 3E2M 3EOA 3EOB 3F74 3F78 3HI6 3M6F 3TCX 4IXD 5E6R 5E6S 5E6U 6BXB 6BXF 6BXJ 6CKB
Enriched GO Terms of Interacting Partners?
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