MED25 and MED15

Number of citations of the paper that reports this interaction (PubMedID 14983011)
61

Data Source:
HPRD (in vivo)

		MED25	MED15
Description		mediator complex subunit 25	mediator complex subunit 15
Image
GO Annotations	Cellular Component	Nucleoplasm Mediator Complex Nuclear Transcription Factor Complex	Nucleoplasm Cytoplasm Membrane Mediator Complex
	Molecular Function	Transcription Coactivator Binding Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding	Transcription Coregulator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Stem Cell Population Maintenance
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Blood trace element (Se levels) ( 23720494)	Lung function (FEV1/FVC) ( 30061609)
Interacting Genes		14 interacting genes: CDK8 CREBBP CTDP1 HCFC1 MED1 MED15 MED6 MED8 MED9 NR3C1 RARA RXRA SREBF1 THRA	12 interacting genes: ATP5F1C ATXN1 CTDP1 FHL3 MED25 MLLT6 PLSCR1 RELA SMAD2 SMAD3 TRIM11 UBC
Entrez ID		81857	51586
HPRD ID		14380	12117
Ensembl ID		ENSG00000104973	ENSG00000099917
Uniprot IDs		M0QZQ2 Q71SY5	B7Z2H7 G3V1P5 Q6PKB8 Q96RN5
PDB IDs		2KY6 2L23 2L6U 2XNF	2GUT
Enriched GO Terms of Interacting Partners?
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