TBL1XR1 and GPS2

Number of citations of the paper that reports this interaction (PubMedID 11931768)
184

Data Source:
HPRD (in vitro)

		TBL1XR1	GPS2
Description		TBL1X receptor 1	G protein pathway suppressor 2
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcriptional Repressor Complex Mitotic Spindle	Nucleus Nucleoplasm Mitochondrion Cytosol Transcriptional Repressor Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Histone Binding Transcription Regulatory Region DNA Binding Protein N-terminus Binding	Transcription Coactivator Activity Transcription Corepressor Activity GTPase Inhibitor Activity Protein Binding Cyclin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Hatching Response To Dietary Excess Regulation Of Transcription By RNA Polymerase II Lipid Catabolic Process Histone Deacetylation Regulation Of Lipid Metabolic Process Multicellular Organism Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II White Fat Cell Differentiation Fat Pad Development Regulation Of Triglyceride Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Inactivation Of MAPK Activity JNK Cascade Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Viral Process Regulation Of Lipid Metabolic Process B Cell Differentiation Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of GTPase Activity Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Receptor Signaling Pathway Response To Mitochondrial Depolarisation Negative Regulation Of Protein K63-linked Ubiquitination
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events	PPARA activates gene expression HDACs deacetylate histones Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events
Drugs
Diseases
GWAS		Asthma ( 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Central corneal thickness ( 31798171 29760442) Chin dimples ( 27182965) Chronotype ( 30696823) Corneal structure ( 23291589) Esophageal cancer ( 21642993) Inflammatory skin disease ( 25574825) Medication use (adrenergics, inhalants) ( 31015401) Pulse pressure ( 30224653)
Interacting Genes		12 interacting genes: ARL2 CORO2A FOXK2 GPS2 H2BC21 H4C14 H4C6 HDAC3 MECP2 NCOR1 TBL1X UBE2I	24 interacting genes: ATF4 C19orf57 CCNA1 CHD3 CNOT2 ELOB EP300 GOLGA2 HDAC1 HDAC3 KRT31 MAP3K7CL NCOR1 NR0B2 PBK PRMT6 RBPMS SESTD1 SETDB1 SPDL1 TBL1X TBL1XR1 TFIP11 TP53
Entrez ID		79718	2874
HPRD ID		15476	11878
Ensembl ID		ENSG00000177565	ENSG00000132522
Uniprot IDs		Q9BZK7	Q13227
PDB IDs		4LG9	2L5G
Enriched GO Terms of Interacting Partners?
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