GPS2 and PBK

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GPS2	PBK
Description		G protein pathway suppressor 2	PDZ binding kinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol Transcriptional Repressor Complex	Nucleus
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity GTPase Inhibitor Activity Protein Binding Cyclin Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Inactivation Of MAPK Activity JNK Cascade Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Viral Process Regulation Of Lipid Metabolic Process B Cell Differentiation Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of GTPase Activity Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Receptor Signaling Pathway Response To Mitochondrial Depolarisation Negative Regulation Of Protein K63-linked Ubiquitination	MAPK Cascade Activation Of MAPK Activity Mitotic Cell Cycle Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To UV Negative Regulation Of Inflammatory Response
Pathways		PPARA activates gene expression HDACs deacetylate histones Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events
Drugs
Diseases
GWAS
Interacting Genes		24 interacting genes: ATF4 C19orf57 CCNA1 CHD3 CNOT2 ELOB EP300 GOLGA2 HDAC1 HDAC3 KRT31 MAP3K7CL NCOR1 NR0B2 PBK PRMT6 RBPMS SESTD1 SETDB1 SPDL1 TBL1X TBL1XR1 TFIP11 TP53	17 interacting genes: ARAF CCNB1 CDK1 CEP126 DLG1 GPRASP1 GPS2 H2AX LNX1 PTEN RAF1 SMAD4 TERT TP53 TRIM37 ZBTB26 ZFP64
Entrez ID		2874	55872
HPRD ID		11878	17822
Ensembl ID		ENSG00000132522	ENSG00000168078
Uniprot IDs		Q13227	Q96KB5 V9HWH0
PDB IDs		2L5G	5J0A
Enriched GO Terms of Interacting Partners?
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