SNRNP25 and LHX4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SNRNP25	LHX4
Description		small nuclear ribonucleoprotein U11/U12 subunit 25	LIM homeobox 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U12-type Spliceosomal Complex Cytosol Intercellular Bridge	Nuclear Chromatin Nucleus
	Molecular Function	Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Splicing	Placenta Development Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		mRNA Splicing - Minor Pathway	Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Body mass index ( 26426971)
Interacting Genes		9 interacting genes: CPSF7 EFHC2 KRT31 LHX4 LNX1 NKAPD1 REL TRAF2 UBC	22 interacting genes: ADAMTSL4 AXIN1 CHCHD2 FDX2 GOLGA2 IFT172 IKZF1 KRT38 KRT40 LDB2 LONRF1 NRF1 ORC6 SH2D1A SNRNP25 SSX1 TCAP TCF4 TP53BP2 TXNDC5 UBQLN1 USP2
Entrez ID		79622	89884
HPRD ID		12673	03686
Ensembl ID		ENSG00000161981	ENSG00000121454
Uniprot IDs		Q4TT61 Q9BV90	A0A0S2Z5S4 Q969G2
PDB IDs			5HOD
Enriched GO Terms of Interacting Partners?
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