MLPH and RAB27B

Number of citations of the paper that reports this interaction (PubMedID 11856727)
99

Data Source:
HPRD (in vivo)

		MLPH	RAB27B
Description		melanophilin	RAB27B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cell Dendrite Cortical Actin Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome	Cell Late Endosome Golgi Apparatus Golgi Stack Plasma Membrane Endomembrane System Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Anchored Component Of Synaptic Vesicle Membrane Axon Cytoplasm
	Molecular Function	Actin Binding Protein Binding Myosin Binding Rab GTPase Binding Protein Binding, Bridging Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Intracellular Protein Transport Melanosome Transport	Platelet Degranulation Intracellular Protein Transport Melanosome Transport Rab Protein Signal Transduction Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport
Pathways			Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29617998) Prostate cancer ( 21743057)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 28892062) Childhood body mass index ( 26604143) Depression ( 29700475) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		4 interacting genes: MTDH MYO5A RAB27A RAB27B	8 interacting genes: DHPS MLPH RPH3AL SYTL1 SYTL2 SYTL4 SYTL5 UNC13D
Entrez ID		79083	5874
HPRD ID		09409	04846
Ensembl ID		ENSG00000115648	ENSG00000041353
Uniprot IDs		A0A024R4D3 Q9BV36	O00194
PDB IDs			2F7S
Enriched GO Terms of Interacting Partners?
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